Introduction: Marfan syndrome is a multisystemic connective tissue disorder caused mainly
by mutations in the fibrillin-1 gene. The entire cardiovascular system is affected in patients …

Highlights•No medical intervention can completely arrest aneurysmal growth.•Drugs with
immediate translational potential in Marfan syndrome include resveratrol, doxycycline …

Marfan syndrome (MFS) is a heritable connective tissue disorder caused by pathogenic
variants in the gene coding for the extracellular matrix protein fibrillin-1. While the disease …

Marfan syndrome (MFS) is a hereditary disorder with numerous pathophysiological effects,
some specifically creating elastic dysfunction in cardiovascular organs. Aortic dilatation …

Marfan syndrome is a genetic disorder of connective tissue with principal manifestations in
the cardiovascular, ocular, and skeletal systems. Cardiovascular disease, mainly …

The translational path from pharmacological insight to effective therapy can be a long one.
We aim to describe the management of Marfan syndrome as a case‐example of how …

Marfan Syndrome (MFS) is a rare connective tissue disorder, resulting from mutations in the
fibrillin-1 gene, characterized by pathologic phenotypes in multiple organs, the most …

Marfan syndrome is an autosomal dominant connective tissue disease with an estimated
incidence of 1 in 5000 individuals. In 90% of cases it is caused by mutations in the gene for …

Background Marfan syndrome is a hereditary disorder affecting the connective tissue and is
caused by a mutation of the fibrillin‐1 (FBN1) gene. It affects multiple systems of the body …

Marfan syndrome (MFS) is a pleiotropic connective tissue disease inherited as an autosomal
dominant trait, due to mutations in the FBN1 gene encoding fibrillin 1. It is an important …