Natural swietenine attenuates diabetic nephropathy by regulating the NF‐κB/NLRP3/Caspase‐1 signaling pathways: In vivo and in vitro study

J Duan, L He, W Deng, M Lu, Y Zhai… - Environmental …, 2022 - Wiley Online Library
Abstract Swietenine (Swi), isolated from Swietenia macrophylla King ameliorates
inflammation and oxidative stress, and diabetic nephropathy has a close connection with …

Piperlongumine attenuates oxidative stress, inflammatory, and apoptosis through modulating the GLUT‐2/4 and AKT signaling pathway in streptozotocin‐induced …

P Xu, J Xiao, S Chi - Journal of Biochemical and Molecular …, 2021 - Wiley Online Library
The current study was done to measure the role of piperlongumine (PL) on hyperglycemia
interrelated oxidative stress‐mediated inflammation and apoptosis, inflammatory stress, and …

Mangiferin attenuates diabetic nephropathy by inhibiting oxidative stress mediated signaling cascade, TNFα related and mitochondrial dependent apoptotic pathways …

PB Pal, K Sinha, PC Sil - PloS one, 2014 - journals.plos.org
Oxidative stress plays a crucial role in the progression of diabetic nephropathy in
hyperglycemic conditions. It has already been reported that mangiferin, a natural C-glucosyl …

Jiangtang decoction ameliorate diabetic nephropathy through the regulation of PI3K/Akt-mediated NF-κB pathways in KK-Ay mice

JN Hong, WW Li, LL Wang, H Guo, Y Jiang, YJ Gao… - Chinese medicine, 2017 - Springer
Background Jiangtang decoction (JTD) is a China patented drug which contains Euphorbia
humifusa Willd, Salvia miltiorrhiza Bunge, Astragalus mongholicus Bunge, Anemarrhena …

RETRACTED: Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK–S1P signaling pathway

T Lan, X Shen, P Liu, W Liu, S Xu, X Xie, Q Jiang, W Li… - 2010 - Elsevier
Berberine (BBR) was previously found to have beneficial effects on renal injury in
experimental diabetic rats. However, the mechanisms underlying the effects are not fully …

Phenylethanoid glycoside verbascoside ameliorates podocyte injury of diabetic kidney disease by regulating NR4A1-LKB1-AMPK signaling

X Chen, M Shi, L Yang, F Guo, Y Liang, L Ma… - Acta Materia …, 2023 - scienceopen.com
Diabetic kidney disease (DKD) is one of the leading causes of end-stage renal disease.
Verbascoside is a ubiquitous phenylethanoid glycoside with potent anti-inflammatory …

[HTML][HTML] Involvement of the TGFβ1-ILK-Akt signaling pathway in the effects of hesperidin in type 2 diabetic nephropathy

YH Zhang, B Wang, F Guo, ZZ Li, GJ Qin - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Diabetic nephropathy is one of the manifestations of systemic microangiopathy in diabetes.
Hesperetin, a natural flavanone glycoside compound in citrus fruits, has been demonstrated …

Geniposide improves diabetic nephropathy by enhancing ULK1-mediated autophagy and reducing oxidative stress through AMPK activation

T Dusabimana, EJ Park, J Je, K Jeong, SP Yun… - International journal of …, 2021 - mdpi.com
Diabetic nephropathy (DN) is a common pathological feature in patients with diabetes and
the leading cause of end-stage renal disease. Although several pharmacological agents …

Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF/Akt/ERK pathways

H Tan, J Chen, Y Li, Y Li, Y Zhong, G Li, L Liu, Y Li - Molecular Medicine, 2022 - Springer
Abstract Background Glabridin (Glab) is a bioactive component of licorice that can
ameliorate diabetes, but its role in diabetic nephropathy (DN) has seldom been reported …

Beneficial effects of phlorizin on diabetic nephropathy in diabetic db/db mice

F Pei, B Li, Z Zhang, F Yu, X Li, Q Cai, H Gao… - Journal of Diabetes and …, 2014 - Elsevier
Aims This study observes the effects of phlorizin on diabetic nephrology in db/db diabetic
mice and explores possible underlying mechanisms. Methods Sixteen diabetic db/db mice …