[HTML][HTML] Baicalin improves podocyte injury in rats with diabetic nephropathy by inhibiting PI3K/Akt/mTOR signaling pathway
Y Ou, W Zhang, S Chen, H Deng - Open Medicine, 2021 - degruyter.com
Objective To investigate the effect of baicalin on diabetic nephropathy (DN) rats and
podocytes and its mechanism. Methods The rat models with DN were established by high-fat …
podocytes and its mechanism. Methods The rat models with DN were established by high-fat …
[HTML][HTML] Therapeutic mechanism and clinical application of Chinese herbal medicine against diabetic kidney disease
DQ Chen, J Wu, P Li - Frontiers in Pharmacology, 2022 - frontiersin.org
Diabetic kidney disease (DKD) is the major complications of type 1 and 2 diabetes, and is
the predominant cause of chronic kidney disease and end-stage renal disease. The …
the predominant cause of chronic kidney disease and end-stage renal disease. The …
[HTML][HTML] Dl-3-n-butylphthalide ameliorates diabetic nephropathy by ameliorating excessive fibrosis and podocyte apoptosis
J Xu, Z Tang, Y He, S Cai, B Wang, S Zhang… - Frontiers in …, 2021 - frontiersin.org
Diabetic nephropathy (DN) is a common diabetes associated complication. Thus, it is
important to understand the pathological mechanism of DN and find the appropriate …
important to understand the pathological mechanism of DN and find the appropriate …
Phloretin as an add-on therapy to losartan attenuates diabetes-induced AKI in rats: a potential therapeutic approach targeting TLR4-induced inflammation
Abstract Aim Targeting Toll-like receptor 4 (TLR4) and Angiotensin II type 1 receptor (AT1R)
could provide renoprotection during acute kidney injury (AKI) mainly by regulating …
could provide renoprotection during acute kidney injury (AKI) mainly by regulating …
[HTML][HTML] LY333531, a PKCβ inhibitor, attenuates glomerular endothelial cell apoptosis in the early stage of mouse diabetic nephropathy via down-regulating swiprosin …
Z Wang, S Zhang, Y Li, R Wang, L Tong… - Acta Pharmacologica …, 2017 - nature.com
Glomerular endothelial cell (GEC) injury plays an important role in the early stage of diabetic
nephropathy (DN). Previous studies show that a PKCβ inhibitor is effective for treating DN. In …
nephropathy (DN). Previous studies show that a PKCβ inhibitor is effective for treating DN. In …
Kaempferol in ameliorating diabetes-induced fibrosis and renal damage: an in vitro and in vivo study in diabetic nephropathy mice model
D Sharma, RK Tekade, K Kalia - Phytomedicine, 2020 - Elsevier
Background Kaempferol is a natural polyflavonol that has gained considerable attention as
antidiabetic therapeutics. Recent reports emphasize the role of hyperglycemia and …
antidiabetic therapeutics. Recent reports emphasize the role of hyperglycemia and …
Geniposide reduces development of streptozotocin‐induced diabetic nephropathy via regulating nuclear factor‐kappa B signaling pathways
X Hu, X Zhang, G Jin, Z Shi, W Sun… - Fundamental & Clinical …, 2017 - Wiley Online Library
Renal pathology was a commonly seen complication in patients with diabetes. Geniposide
(GPO) was previously demonstrated to modulate glucose metabolism in diabetes. This study …
(GPO) was previously demonstrated to modulate glucose metabolism in diabetes. This study …
[HTML][HTML] Phillygenin attenuates inflammatory responses and influences glucose metabolic parameters by inhibiting Akt activity
W Liu, G Chu, N Chang, X Ma, M Jiang, G Bai - Rsc Advances, 2017 - pubs.rsc.org
Phillygenin (Phi) is one of the main chemical constituents of the fruit of Forsythia suspensa
(Thunb.) Vahl. It has various bioactivities, including anti-inflammatory, anti-obesity and …
(Thunb.) Vahl. It has various bioactivities, including anti-inflammatory, anti-obesity and …
[HTML][HTML] Additive renal protective effects between arctigenin and puerarin in diabetic kidney disease
X Li, J Wang, J Yan, JC He, Y Li, Y Zhong - Biomedicine & …, 2024 - Elsevier
Recent studies have shown that the combined use of renin angiotensin system inhibitor,
SGLT2 inhibitors and/or mineralocorticoid receptor antagonist provides additional renal …
SGLT2 inhibitors and/or mineralocorticoid receptor antagonist provides additional renal …
Lupenone improves type 2 diabetic nephropathy by regulating NF-κB pathway-mediated inflammation and TGF-β1/Smad/CTGF-associated fibrosis
H Wu, F Xu, X Huang, X Li, P Yu, L Zhang, X Yang… - Phytomedicine, 2023 - Elsevier
Background Type 2 diabetic nephropathy is a common diabetic complication and the main
cause of death in patients with diabetes. Research has aimed to find an ideal drug with …
cause of death in patients with diabetes. Research has aimed to find an ideal drug with …