Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs

EME Hedlund, X Yang, Y Zhang… - Proceedings of the …, 2013 - National Acad Sciences
The role of placental growth factor (PlGF) in modulation of tumor angiogenesis and tumor
growth remains an enigma. Furthermore, anti-PlGF therapy in tumor angiogenesis and …

Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth

X Yang, Y Zhang, Y Yang, S Lim… - Proceedings of the …, 2013 - National Acad Sciences
Placental growth factor (PlGF) remodels tumor vasculatures toward a normalized phenotype,
which affects tumor growth, invasion and drug responses. However, the coordinative and …

[HTML][HTML] Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers

A Eriksson, R Cao, R Pawliuk, SM Berg, M Tsang… - Cancer cell, 2002 - cell.com
Tumor growth and metastasis require concomitant growth of new blood vessels, which are
stimulated by angiogenic factors, including vascular endothelial growth factor (VEGF) …

[HTML][HTML] PlGF blockade does not inhibit angiogenesis during primary tumor growth

C Bais, X Wu, J Yao, S Yang, Y Crawford… - Cell, 2010 - cell.com
It has been recently reported that treatment with an anti-placenta growth factor (PlGF)
antibody inhibits metastasis and primary tumor growth. Here we show that, although anti …

Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic …

L Xu, DM Cochran, RT Tong, F Winkler, S Kashiwagi… - Cancer research, 2006 - AACR
The role of placenta growth factor (PlGF) in pathologic angiogenesis is controversial. The
effects of PlGF on growth, angiogenesis, and metastasis from orthotopic tumors are not …

Placental growth factor upregulation is a host response to antiangiogenic therapy

RG Bagley, Y Ren, W Weber, M Yao, L Kurtzberg… - Clinical Cancer …, 2011 - AACR
Abstract Purpose: Placental growth factor (PlGF) is an angiogenic protein. Upregulation of
PlGF has been observed in the clinic following antiangiogenic regimens targeting the VEGF …

[HTML][HTML] Increased expression of placental growth factor in high-grade endometrial carcinoma

L Coenegrachts, S Schrauwen… - Oncology …, 2013 - spandidos-publications.com
Placental growth factor (PlGF), a homolog of vascular endothelial growth factor (VEGF),
exerts pleiotropic functions in cancer by affecting tumor cells as well as endothelial and …

Altered tumor vessel maturation and proliferation in placenta growth factor‐producing tumors: potential relationship to post‐therapy tumor angiogenesis and …

AP Taylor, M Rodriguez, K Adams… - … journal of cancer, 2003 - Wiley Online Library
Cells in human tumor xenografts express similar levels of angiogenic growth factors before
treatment. After radioimmunotherapy (RAIT) surviving tumor cells upregulate angiogenic …

A placental growth factor variant unable to recognize vascular endothelial growth factor (VEGF) receptor-1 inhibits VEGF-dependent tumor angiogenesis via …

V Tarallo, L Vesci, O Capasso, MT Esposito, T Riccioni… - Cancer research, 2010 - AACR
Angiogenesis is one of the crucial events for cancer development and growth. Two members
of the vascular endothelial growth factor (VEGF) family, VEGF-A and placental growth factor …

Placenta growth factor is over-expressed and has prognostic value in human breast cancer

C Parr, G Watkins, M Boulton, J Cai… - European Journal of …, 2005 - Elsevier
Placenta growth factor (PlGF) belongs to the vascular endothelial growth factor (VEGF)
family, a group of angiogenic factors that are crucial for tumour angiogenesis. Very little is …