[HTML][HTML] Full functional knockout of placental growth factor by knockin with an inactive variant able to heterodimerize with VEGF-A

I Apicella, V Cicatiello, D Acampora, V Tarallo… - Cell reports, 2018 - cell.com
Placental growth factor (PlGF) is a proangiogenic member of the vascular endothelial growth
factor (VEGF) family playing a central role in pathological angiogenesis. PlGF-DE is a PlGF …

The discovery of the placental growth factor and its role in angiogenesis: a historical review

D Ribatti - Angiogenesis, 2008 - Springer
The placental growth factor (PlGF) is an angiogenic protein belonging to the vascular
endothelial growth factor (VEGF) family, which was discovered in 1991 by an Italian …

Genetic dissection of tumor angiogenesis: are PlGF and VEGFR-1 novel anti-cancer targets?

A Luttun, M Autiero, M Tjwa, P Carmeliet - Biochimica et Biophysica Acta …, 2004 - Elsevier
Many proliferative diseases, most typically cancer, are driven by uncontrolled blood vessel
growth. Genetic studies have been very helpful in unraveling the cellular and molecular …

[HTML][HTML] αPlGF: a new kid on the antiangiogenesis block

RK Jain, L Xu - Cell, 2007 - cell.com
An agent that blocks tumor angiogenesis, growth, and metastasis without affecting normal
tissues—whether used alone or in combination with currently approved drugs—would …

Structure and function of placental growth factor

S De Falco, B Gigante, MG Persico - Trends in cardiovascular medicine, 2002 - Elsevier
Placental growth factor (PlGF) belongs to the same family as the vascular endothelial growth
factor A (VEGF-A). Recent gene inactivation studies in mice have demonstrated that loss of …

Upregulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (PlGF) associated with malignancy in human thyroid tumors …

G Viglietto, D Maglione, M Rambaldi, J Cerutti… - Oncogene, 1995 - europepmc.org
Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells in vitro,
promotes neoangiogenesis in vivo and increases the permeability of the vascular …

[HTML][HTML] A placenta growth factor 2 variant acts as dominant negative of vascular endothelial growth factor A by heterodimerization mechanism

V Tarallo, L Tudisco, S De Falco - American journal of cancer …, 2011 - ncbi.nlm.nih.gov
Angiogenesis is one of the crucial events for cancer development and growth and vascular
endothelial growth factor (VEGF) family plays an essential role in this biological …

Placental Growth Factor (PlGF) and Its Receptor Flt‐1 (VEGFR‐1) Novel Therapeutic Targets for Angiogenic Disorders

A Luttun, M Tjwa, P Carmeliet - … of the New York Academy of …, 2002 - Wiley Online Library
Efforts to therapeutically stimulate or inhibit vessel growth have been primarily focused on
vascular endothelial growth factor (VEGF) and its receptor VEGFR‐2 (Flk‐1), while little …

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions

P Carmeliet, L Moons, A Luttun, V Vincenti… - Nature medicine, 2001 - nature.com
Vascular endothelial growth factor (VEGF) stimulates angiogenesis by activating VEGF
receptor-2 (VEGFR-2). The role of its homolog, placental growth factor (PlGF), remains …

[PDF][PDF] Placenta growth factor is abundantly expressed in human cervical squamous cell carcinoma.

J Kodama, N Seki, K Tokumo, Y Nakanishi… - Placenta, 1997 - article.imrpress.com
Tumor angiogenesis is essential for solid tumor growth. The object of this study was to
investigate the presence of newly identified angiogenic factor, placenta growth factor (P1GF) …