Background Since its initiation in 2005, the Harvard Personal Genome Project has enrolled
thousands of volunteers interested in publicly sharing their genome, health and trait data …

The revolution in DNA sequencing technologies has now made it feasible to determine the
genome sequences of many individuals; ie,“personal genomes.” Genome sequences of …

The promise of personalized medicine depends on the ability to integrate genetic
sequencing information into disease risk assessment for individuals. As genomic …

In addition to provocative questions about science policy, research on the human genome
will generate important ethical questions in at least three categories. First, the possibility of …

Background Rapid advances in high throughput genomic technologies and next generation
sequencing are making medical genomic research more readily accessible and affordable …

The sequencing and subsequent publication of the human genome (1, 2) captured the
public imagination and marked the beginning of a new era in biological research. An …

Despite extensive debate, there is no consensus on whether individual genetic data should
be disclosed to research participants. The emergence of whole-genome sequencing …

Objective The development of genomic approaches to prenatal testing such as whole
genome and exome sequencing offers the potential for a better understanding of prenatal …

Technological advances often outpace our ability to effec-tively use them, a situation that
certainly could pertain to modern genomics. Breathtaking advances in genetic sequencing …

The development of new massive sequencing techniques has now made it possible to
significantly reduce the time and costs of whole-genome sequencing (WGS). Although WGS …