Protein kinase CK2 (Casein Kinase 2) is an extremely pleiotropic Ser/Thr kinase with high
constitutive activity. The observation of CK2 deregulations in various pathological processes …

CK2 is a very pleiotropic protein kinase whose high constitutive activity is suspected to
cooperate to neoplasia. Here, the crystal structure of the complexes between CK2 and three …

A new series of 2-amino-4-phenyl-6-hydroxy-7-alkyl-pyranobenzoquinones was
synthesized as ATP-competitive CK2 inhibitors. They were readily synthesized through a …

Protein kinase CK2 is an emerging target for therapeutic intervention in human diseases,
particularly in cancer. Inhibitors of this enzyme are currently in clinical trials, indicating the …

The interaction of human CK2α (hCK2α) with nine halogenated benzotriazoles, TBBt and its
analogues representing all possible patterns of halogenation on the benzene ring of …

Protein kinase CK2, also known as casein kinase-2, is involved in a broad range of
physiological events including cell growth, proliferation and suppression of apoptosis which …

Protein kinase CK2 is a highly pleiotropic protein kinase capable of phosphorylating
hundreds of protein substrates. It is involved in numerous cellular functions, including cell …

Abstract Background Casein kinase 2 (CK2) is dysregulated in various human cancers and
is a promising target for cancer therapy. To date, there is no small molecular CK2 inhibitor in …

Methods Recombinant human protein kinase CK2 alpha'and beta subunits were cloned and
expressed by gene engineering, and purified to homogeneous. These 2 subunits were …

A series of novel iodinated benzimidazoles have been prepared by iodination of respective
benzimidazole with iodine and periodic acid in sulfuric acid solution. Additionally several 2 …