The alkyloid compound ellipticine derived from the berrywood tree is a topoisomerase II
poison that is used in ovarian and breast cancer treatment. In this study, we report the …

Protein kinase 2 (CK2) is a potential target, and the coumarins were identified as the
attractive CK2 inhibitors. In this study, two models (CoMFA and CoMSIA) were established …

CK2 is a Ser/Thr kinase recruited by tumor cells to avoid cell death. 4′-Carboxy-6, 8-
dibromo-flavonol (FLC26) is a nanomolar CK2 inhibitor reducing the physiological …

Protein kinase CK2 has been considered as an attractive drug target for anti-cancer therapy.
The synthesis of N-hydroxypropyl TBBi and 2MeTBBi derivatives as well as their respective …

A series of new polybrominated benzimidazoles and benzotriazoles has been synthesized
and their influence on the activity of protein kinase CK2 was evaluated. It was revealed that …

Protein kinase CK2 is a potential drug target for many diseases including cancer and
inflammation disorders. The crystal structure of clinical candidate CX-4945 1 with CK2 …

The new aminoalkyl-substituted derivatives of known CK2 inhibitors 4, 5, 6, 7-tetrabromo-1H-
benzimidazole (TBBi) and 4, 5, 6, 7-tetrabromo-1H-benzotriazole (TBBt) were synthesized …

Protein kinase CK2 has been considered as an attractive therapeutic target of cancer
therapy. The tricyclic quinoline compound CX-4945 is the first representative of CK2 …

Identification of new small molecules inhibiting protein kinase CK2 is highly required for the
study of this protein's functions in cell and for the further development of novel …

Herein we chronicle the discovery of CX-4945 (25n), a first-in-class, orally bioavailable ATP-
competitive inhibitor of protein kinase CK2 in clinical trials for cancer. CK2 has long been …