Lessons from the past and charting the future of marine natural products drug discovery and chemical biology

WH Gerwick, BS Moore - Chemistry & biology, 2012 - cell.com
Marine life forms are an important source of structurally diverse and biologically active
secondary metabolites, several of which have inspired the development of new classes of …

Drugs from the oceans: Marine natural products as leads for drug discovery

KH Altmann - Chimia, 2017 - ojs.chimia.ch
The marine environment harbors a vast number of species that are the source of a wide
array of structurally diverse bioactive secondary metabolites. At this point in time, roughly …

A renaissance in marine pharmacology: from preclinical curiosity to clinical reality

KB Glaser, AMS Mayer - Biochemical pharmacology, 2009 - Elsevier
Marine pharmacology, the pharmacology of marine natural products, has been for some
time more associated with marine natural products chemistry rather than mainstay …

Unlocking the potential of marine biodiscovery

JD Sigwart, R Blasiak, M Jaspars, JB Jouffray… - Natural Product …, 2021 - pubs.rsc.org
The tremendous diversity of life in the ocean has proven to be a rich source of inspiration for
drug discovery, with success rates for marine natural products up to 4 times higher than …

Advances in exploring the therapeutic potential of marine natural products

X Liang, D Luo, H Luesch - Pharmacological research, 2019 - Elsevier
Marine natural products represent novel and diverse chemotypes that serve as templates for
the discovery and development of therapeutic agents with distinct mechanisms of action …

[PDF][PDF] Marine natural products as sources of novel scaffolds: Achievement and concern

DX Kong, YY Jiang, HY Zhang - Drug discovery today, 2010 - academia.edu
From past to present, drug discovery has been tightly coupled with natural products. Not only
were traditional medicines composed of natural agents, but also a large proportion ($50%) …

Drugs and cosmetics from the sea

A Kijjoa, P Sawangwong - Marine Drugs, 2004 - mdpi.com
The marine environment is a rich source of both biological and chemical diversity. This
diversity has been the source of unique chemical compounds with the potential for industrial …

Marine drugs: implication and future studies

S Vignesh, A Raja, RA James - 2011 - agris.fao.org
Natural product compounds are the source of numerous therapeutic agents. Recent
progress to discover drugs from natural product sources has resulted in compounds that are …

Marine natural products: a new wave of drugs?

R Montaser, H Luesch - Future medicinal chemistry, 2011 - Taylor & Francis
The largely unexplored marine world that presumably harbors the most biodiversity may be
the vastest resource to discover novel 'validated'structures with novel modes of action that …

The marine biodiscovery pipeline and ocean medicines of tomorrow

M Jaspars, D De Pascale, JH Andersen… - Journal of the Marine …, 2016 - cambridge.org
Marine organisms possess the capacity to produce a variety of unique and biologically
potent natural products for treating human diseases, many of which are currently …