The update on transcriptional regulation of autophagy in normal and pathologic cells: A novel therapeutic target

Z Zhang, M Guo, S Zhao, W Xu, J Shao, F Zhang… - Biomedicine & …, 2015 - Elsevier
Autophagy is a genetically programmed, evolutionarily conserved catabolic process that
occurs in response to stress. While short-lived proteins are degraded via the …

Aberrant regulation of autophagy in mammalian diseases

W Xie, J Zhou - Biology letters, 2018 - royalsocietypublishing.org
Autophagy is a major cellular metabolic pathway that facilitates degradation of a subset of
long-lived proteins and cytoplasmic organelles in eukaryotic cells. This pathway plays a vital …

[HTML][HTML] Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets

F Shu, H Xiao, QN Li, XS Ren, ZG Liu, BW Hu… - … and Targeted Therapy, 2023 - nature.com
Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

Autophagy: The spotlight for cellular stress responses

P Ravanan, IF Srikumar, P Talwar - Life sciences, 2017 - Elsevier
Autophagy is an essential cellular mechanism which plays “housekeeping” role in normal
physiological processes including removing of long lived, aggregated and misfolded …

Autophagy: Can it become a potential therapeutic target?

XH Bao, Y Naomoto, HF Hao… - International …, 2010 - spandidos-publications.com
Autophagy is a cellular lysosomal degradation pathway involved in proteins and organelles
recycling for promoting cell survival, development and homeostasis. It is a multistep process …

[HTML][HTML] Autophagy modulation as a potential therapeutic target for diverse diseases

DC Rubinsztein, P Codogno, B Levine - Nature reviews Drug discovery, 2012 - nature.com
Autophagy is an essential, conserved lysosomal degradation pathway that controls the
quality of the cytoplasm by eliminating protein aggregates and damaged organelles. It …

Autophagy in human health and disease: novel therapeutic opportunities

F Giampieri, S Afrin, TY Forbes-Hernandez… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: In eukaryotes, autophagy represents a highly evolutionary conserved process,
through which macromolecules and cytoplasmic material are degraded into lysosomes and …

Autophagy in disease: a double-edged sword with therapeutic potential

W Martinet, P Agostinis, B Vanhoecke… - Clinical …, 2009 - portlandpress.com
Autophagy is a catabolic trafficking pathway for bulk destruction and turnover of long-lived
proteins and organelles via regulated lysosomal degradation. In eukaryotic cells, autophagy …

[HTML][HTML] Highlights in Autophagy—From Basic Mechanisms to Human Disorder Treatments

PH Lin, L Combaret - Cells, 2023 - mdpi.com
Autophagy is an evolutionarily conserved catabolic process and represents a field of
research that is constantly growing. Autophagy degrades cellular proteins, damaged/or …

Mechanism and medical implications of mammalian autophagy

I Dikic, Z Elazar - Nature reviews Molecular cell biology, 2018 - nature.com
Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …