Inflammation: a novel therapeutic target/direction in atherosclerosis

B Li, W Li, X Li, H Zhou - Current Pharmaceutical Design, 2017 - ingentaconnect.com
Over the past two decades, the viewpoint of atherosclerosis has been replaced gradually by
a lipiddriven, chronic, low-grade inflammatory disease of the arterial wall. Current treatment …

Tackling inflammation in atherosclerosis: Are we there yet and what lies beyond?

P Bhattacharya, R Kanagasooriyan… - Current Opinion in …, 2022 - Elsevier
Atherosclerosis is a lipid-driven disease of the artery characterized by chronic non-resolving
inflammation. Despite availability of excellent lipid-lowering therapies, atherosclerosis …

Anti-inflammatory therapeutics for the treatment of atherosclerosis

IF Charo, R Taub - Nature reviews Drug discovery, 2011 - nature.com
Atherosclerosis is the primary cause of heart disease and stroke and is thus the underlying
pathology of the leading causes of death in the western world. Although risk can be reduced …

Inflammation as a therapeutic target in atherosclerosis

MT Nguyen, S Fernando, N Schwarz, JTM Tan… - Journal of clinical …, 2019 - mdpi.com
Atherosclerotic coronary artery disease (CAD) results from build-up of cholesterol-rich
plaques in the walls of the coronary arteries and is a leading cause of death. Inflammation is …

Inflammatory therapeutic targets in coronary atherosclerosis—from molecular biology to clinical application

F Linden, G Domschke, C Erbel… - Frontiers in …, 2014 - frontiersin.org
Atherosclerosis is the leading cause of death worldwide. Over the past two decades, it has
been clearly recognized that atherosclerosis is an inflammatory disease of the arterial wall …

Targeting inflammation in atherosclerosis—from experimental insights to the clinic

O Soehnlein, P Libby - Nature reviews Drug discovery, 2021 - nature.com
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …

Updating concepts on atherosclerotic inflammation: From pathophysiology to treatment

S Ministrini, F Carbone… - European Journal of …, 2021 - Wiley Online Library
Background Atherosclerosis is recognized as a systemic low‐grade inflammatory disease.
Furthermore, the dysregulation of the inflammatory response and its timely resolution is a …

Inflammation in coronary atherosclerosis: insights into pathogenesis and therapeutic potential of anti-inflammatory drugs

CS Figueiredo, ES Roseira, TT Viana, MAD Silveira… - Pharmaceuticals, 2023 - mdpi.com
Atherosclerosis is a lipid-driven immune-inflammatory disease that affects the arteries,
leading to multifocal plaque development. The inflammatory process involves the activation …

Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

P Kong, ZY Cui, XF Huang, DD Zhang… - Signal transduction and …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions

P Raggi, J Genest, JT Giles, KJ Rayner, G Dwivedi… - Atherosclerosis, 2018 - Elsevier
Abstract Rudolph Virchow (1821–1902) recognized inflammation in histological
preparations of coronary arteries and proposed that inflammation plays a causal role in …