Objective: To investigate whether mTOR signaling pathway regulate the proliferation and
differentiation of CD8+ T cells by transcription factors T-bet and Eomes, and explore the role …

Excessive inflammation by phagocytes during Aspergillus fumigatus infection is thought to
promote lung function decline in CF patients. CFTR modulators have been shown to reduce …

Background Immune defects in chronic pulmonary aspergillosis (CPA) are poorly
characterized. We compared peripheral blood cytokine profiles in patients with CPA versus …

Studies with non-immunocompromised mice have demonstrated that Aspergillus flavus is
more virulent than almost all other Aspergillus species. However, the type of immune …

Aspergillus fumigatus conidia are the most prevalent indoors fungal allergens. The
interaction between Aspergillus antigens and lung epithelial cells (LECs) result in innate …

Aspergillus fumigatus is an important human respiratory mould pathogen. In addition to a
barrier function, airway epithelium elicits a robust defence against inhaled A. fumigatus by …

Inhalation of airborne conidia of the ubiquitous fungus Aspergillus fumigatus commonly
occurs but invasive aspergillosis is rare except in profoundly immunocompromised persons …

The interplay between Aspergillus fumigatus and the host immune response in lung
infection has been subject of studies over the last years due to its importance in …

Exposure to mold-contaminated indoor air has been associated with various respiratory
diseases, and there is a need for experimental data to confirm these associations. The pro …

Background Sensitisation with Aspergillus fumigatus (Af) is known to be associated with
severe allergic lung inflammation, but the mechanism remains to be clarified …