In the present investigation, few 3-(substitutedphenyl)-1-[2-(1-hydroxy-ethyl)]-1H-
benzimidazol-1-yl) prop-2-en-1-ones are EGFR antagonist are designed, by molecular …

Epidermal growth factor receptor (EGFR), one of the important targets in the development of
the anticancer compound, is a member of the ErbB receptor tyrosine kinase receptor family …

Background: Cancer is a devastating disease. Many studies have shown that the primary
causes of the aggressive and resistant types of cancer are the overexpression of receptors …

Some novel benzimidazole and pyrazinobenzimidazole derivatives 5-8 was designed for
evaluation of their in vitro cytotoxicity studies using MTT-based assay against three cancer …

Epidermal growth factor receptors (EGFR) are critical for the growth of many tumors and
expressed at high levels in about one third of epithelial cancers. Hence, blockade of the …

Benzimidazole is an isostere of purine nucleosides so; it is widely used as a basic nucleus
in the development of different anticancer agents. Receptor tyrosine kinases (RTK) was …

Background: The studies on the potential usage of benzene sulfonamide derivatives as
anticancer agents are limited. benzene sulfonamide derivatives are currently used as …

Background: Cancer is a group of illnesses characterised by the impartial increase and
unfolding of somatic cells. A variety of natural compounds, such as curcumin, zingiberine …

A novel series of Benzothiazepine derivatives were designed and evaluated for epidermal
growth factor receptor (EFGR) inhibitory potential by using various computational tools along …

Objectives This study aims to synthesize a series of benzoxazines (1–5) to be examined as
an epidermal growth factor receptor (EGFR) inhibitor by in-silico study. The overexpression …