Treatment of isolated systolic hypertension in the elderly: further evidence from the systolic hypertension in Europe (Syst-Eur) trial

JA Staessen, L Thijs, J Gąsowski, RH Fagard… - The American journal of …, 1998 - Elsevier
The Systolic Hypertension in Europe (Syst-Eur) study investigated whether antihypertensive
treatment could decrease the risk of cardiovascular complications in elderly patients with …

Treatment of isolated systolic hypertension in the elderly: the Syst-Eur trial

RH Fagard, JA Staessen - Clinical and Experimental Hypertension, 1999 - Taylor & Francis
The Syst-Eur study investigated whether active antihypertensive treatment could reduce
cardiovascular complications in elderly patients with isolated systolic hypertension …

Risk and benefit of treatment of isolated systolic hypertension in the elderly: evidence from the Systolic Hypertension in Europe Trial

H Celis, RH Fagard, JA Staessen… - Current opinion in …, 2001 - journals.lww.com
Abstract The Syst-Eur trial investigated whether active treatment starting with the
dihydropyridine calcium channel blocker (CCB) nitrendipine, could reduce the …

Subgroup and per-protocol analysis of the randomized European Trial on Isolated Systolic Hypertension in the Elderly

JA Staessen, R Fagard, L Thijs, H Celis… - Archives of internal …, 1998 - jamanetwork.com
Background In 1989, the European Working Party on High Blood Pressure in the Elderly
started the double-blind, placebo-controlled, Systolic Hypertension in Europe Trial to test the …

Overview of the outcome trials in older patients with isolated systolic hypertension

JA Staessen, JG Wang, L Thijs, R Fagard - Journal of human …, 1999 - nature.com
Aims: Isolated systolic hypertension affects over 8 to 15% of all subjects older than 60 years.
In the elderly, systolic hypertension is the major modifiable cardiovascular risk factor. Three …

Trials in isolated systolic hypertension: an update

B Waeber - Current hypertension reports, 2003 - Springer
Isolated systolic hypertension (ISH) has proved to be a powerful predisposing factor for
cardiovascular diseases in the elderly. Recent placebo-controlled interventional trials such …

Hypertension as a function of age

GF Gensini, F Corradi - Italian Heart Journal: Official Journal of the …, 2000 - europepmc.org
Hypertension is one of the main risk factors for cerebrovascular disease (stroke), coronary
artery disease (acute myocardial infarction), congestive heart failure (both systolic and …

Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials

JA Staessen, J Gasowski, JG Wang, L Thijs… - The Lancet, 2000 - thelancet.com
Background Previous meta-analysis of outcome trials in hypertension have not specifically
focused on isolated systolic hypertension or they have explained treatment benefit mainly in …

Antihypertensive efficacy and tolerability of different drug regimens in isolated systolic hypertension in the elderly

F Avanzini, C Alli, G Bettelli, R Corso… - European heart …, 1994 - academic.oup.com
The pharmacological treatment, mainly based on diuretics, of isolated systolic hypertension
(ISH) has recently been shown to reduce the risk of stroke and coronary heart disease in the …

The benefit of treating isolated systolic hypertension

JG Wang, JA Staessen - Current hypertension reports, 2001 - Springer
Isolated systolic hypertension affects over 15% of all people older than 60 years of age. In
the elderly, systolic hypertension is a major modifiable cardiovascular risk factor. Systolic …