The differential response of proteins to macromolecular crowding
M Candotti, M Orozco - PLoS computational biology, 2016 - journals.plos.org
The habitat in which proteins exert their function contains up to 400 g/L of macromolecules,
most of which are proteins. The repercussions of this dense environment on protein …
most of which are proteins. The repercussions of this dense environment on protein …
Atomistic modeling of intrinsically disordered proteins under polyethylene glycol crowding: quantitative comparison with experimental data and implication of protein …
The malleability of intrinsically disordered proteins (IDPs) has generated great interest in
understanding how their conformations respond to crowded cellular environments …
understanding how their conformations respond to crowded cellular environments …
Specific interactions and environment flexibility tune protein stability under extreme crowding
Macromolecular crowding influences protein mobility and stability in vivo. A precise
description of the crowding effect on protein thermal stability requires the estimate of the …
description of the crowding effect on protein thermal stability requires the estimate of the …
All-atom simulations of crowding effects on ubiquitin dynamics
LA Abriata, E Spiga, M Dal Peraro - Physical biology, 2013 - iopscience.iop.org
It is well-known that crowded environments affect the stability of proteins, with strong
biological and biotechnological implications; however, beyond this, crowding is also …
biological and biotechnological implications; however, beyond this, crowding is also …
On protein folding in crowded conditions
The interior of a cell is a highly packed environment that can be occupied up to 40% by
different macromolecules. Such crowded media influence different biochemical processes …
different macromolecules. Such crowded media influence different biochemical processes …
Effects of macromolecular crowding agents on protein folding in vitro and in silico
Proteins fold and function inside cells which are environments very different from that of
dilute buffer solutions most often used in traditional experiments. The crowded milieu results …
dilute buffer solutions most often used in traditional experiments. The crowded milieu results …
Macromolecular crowding and intrinsically disordered proteins: a polymer physics perspective
The cell is a crowded environment where a relevant fraction of the available space is
occupied by proteins, nucleic acids, and metabolites. Here we discuss recent advancements …
occupied by proteins, nucleic acids, and metabolites. Here we discuss recent advancements …
Optimized OPEP force field for simulation of crowded protein solutions
S Timr, S Melchionna, P Derreumaux… - The Journal of …, 2023 - ACS Publications
Macromolecular crowding has profound effects on the mobility of proteins, with strong
implications on the rates of intracellular processes. To describe the dynamics of crowded …
implications on the rates of intracellular processes. To describe the dynamics of crowded …
Effects of macromolecular crowding on protein folding and aggregation studied by density functional theory: dynamics
AR Kinjo, S Takada - Physical Review E, 2002 - APS
Inside the living cell is inherently crowded with proteins and other macromolecules. Thus, it
is indispensable to take into account various interactions between the protein and other …
is indispensable to take into account various interactions between the protein and other …
Effects of macromolecular crowding on the conformational ensembles of disordered proteins
Due to their conformational malleability, intrinsically disordered proteins (IDPs) are
particularly susceptible to influences of crowded cellular environments. Here we report a …
particularly susceptible to influences of crowded cellular environments. Here we report a …