Substance P (SP), an 11-amino-acid neuropeptide, has long been considered an effector of
pain. However, accumulating studies have proposed a paradoxical role of SP in anti …

Substance P (SP) is a highly conserved member of the tachykinin peptide family that is
widely expressed throughout the animal kingdom. The numerous members of the tachykinin …

Release of substance P (SP) from nociceptive nerve fibers and activation of its receptor
neurokinin 1 (NK1) are important effectors in the transmission of pain signals. Nonetheless …

In mammals, somatosensory input activates feedback and feed-forward inhibitory circuits
within the spinal cord dorsal horn to modulate sensory processing and thereby affecting …

Background: Although substance P (SP) is an important primary afferent modulator in
nociceptive processes, it is unclear whether SP regulates its own release from primary …

Substance P is a neuropeptide made up of 11 amino acids—an undecapeptide—and is a
part of the tachykinin neuropeptide family. Its receptor, neurokinin type 1 (NK-1R), is a …

The undecapeptide substance P is expressed by primary afferent neurons where it is
considered to be a cotransmitter of other peptides and glutamate. Since it is predominantly …

The neuropeptide substance P (SP) is known to play a key role in peripheral nociceptive
processes. We investigated the in vitro pharmacological characteristics of functional …

Substance P (SP) is a neuropeptide that mediates numerous physiological responses,
including transmission of pain and inflammation through the neurokinin-1 (NK1) receptor, a …

Background: Substance P is an important neuropeptide released from nociceptors to
mediate pain signals. We recently revealed antinociceptive signaling by substance P in acid …