Cryptococcus infections represents a major healthcare burden, with over 200,000 cases
globally a year and even with treatment, mortality remains as high as 80%. There is a clear …

Macrophages are key cellular components of innate immunity, acting as the first line of
defense against pathogens to modulate homeostatic and inflammatory responses. They …

Monocytes are considered to play a central role in the pathogenesis of Cryptococcus
neoformans infection. Monocytes and monocyte-derived macrophages and dendritic cells …

The vast majority of infection with cryptococcal species occurs with Cryptococcus
neoformans in the severely immunocompromised. A significant exception to this is the …

Opportunistic pathogens have become of increasing medical importance over the last
decade due to the AIDS pandemic. Not only is cryptococcosis the fourth-most-common fatal …

The interaction of pathogenic Cryptococcus species with their various hosts is somewhat
unique compared to other fungal pathogens such as Aspergillus fumigatus and Candida …

Cryptococcus neoformans and Cryptococcus gatti are the etiological agents of
cryptococcosis, a life-threatening mycosis affecting the central nervous system. Cryptococcal …

Cryptococcus neoformans and C. gattii are fungal pathogens that cause life-threatening
disease. These fungi commonly enter their host via inhalation into the lungs where they …

Cryptococcosis occurs most frequently in immunocompromised individuals. This has led to
the prevailing view that this disease is the result of weak immune responses that cannot …

The human fungal pathogens Cryptococcus neoformans and C. gattii cause life-threatening
infections of the central nervous system. One of the major characteristics of cryptococcal …