[HTML][HTML] Therapeutic modification of hypoxia
MR Horsman, BS Sørensen, M Busk, DW Siemann - Clinical Oncology, 2021 - Elsevier
Regions of reduced oxygenation (hypoxia) are a characteristic feature of virtually all animal
and human solid tumours. Numerous preclinical studies, both in vitro and in vivo, have …
and human solid tumours. Numerous preclinical studies, both in vitro and in vivo, have …
Clinical biomarkers for hypoxia targeting
QT Le, D Courter - Cancer and Metastasis Reviews, 2008 - Springer
Tumor hypoxia or a reduction of the tissue oxygen tension is a key microenvironmental
factor for tumor progression and treatment resistance in solid tumors. Because hypoxic …
factor for tumor progression and treatment resistance in solid tumors. Because hypoxic …
The impact of hypoxia and its modification of the outcome of radiotherapy
MR Horsman, J Overgaard - Journal of radiation research, 2016 - academic.oup.com
Since the initial observations made at the beginning of the last century, it has been
established that solid tumors contain regions of low oxygenation (hypoxia). Tumor cells can …
established that solid tumors contain regions of low oxygenation (hypoxia). Tumor cells can …
Tumour hypoxia
CML West, F Slevin - 2019 - christie.openrepository.com
Highlights• Oxygen fixes DNA damage by free radicals and cells are 2–3 times more
radioresistant to sparsely ionising radiation when irradiated in the absence of oxygen.• OER …
radioresistant to sparsely ionising radiation when irradiated in the absence of oxygen.• OER …
Hypoxia and predicting radiation response
RP Hill, RG Bristow, A Fyles, M Koritzinsky… - Seminars in radiation …, 2015 - Elsevier
The results from many studies indicate that most solid tumors, regardless of site of origin,
contain hypoxic regions. Experimental studies have demonstrated that, apart from the well …
contain hypoxic regions. Experimental studies have demonstrated that, apart from the well …
Tumor hypoxia: impact on radiation therapy and molecular pathways
BS Sørensen, MR Horsman - Frontiers in oncology, 2020 - frontiersin.org
Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to
an inadequate, and heterogeneous vascular network. It is associated with resistance to …
an inadequate, and heterogeneous vascular network. It is associated with resistance to …
Tumor hypoxia: a target for selective cancer therapy
Tumor hypoxia has been considered to be a potential therapeutic problem because it
renders solid tumors more resistant to sparsely ionizing radiation (IR) and chemotherapeutic …
renders solid tumors more resistant to sparsely ionizing radiation (IR) and chemotherapeutic …
Hypoxia and radiation therapy: past history, ongoing research, and future promise
S Rockwell, IT Dobrucki, EY Kim… - Current molecular …, 2009 - ingentaconnect.com
Tumor hypoxia influences the outcome of treatment with radiotherapy, chemotherapy and
even surgery, not only for the treatment of large bulky tumors with extensive necrosis, but …
even surgery, not only for the treatment of large bulky tumors with extensive necrosis, but …
The clinical significance of hypoxia in human cancers
N Dhani, A Fyles, D Hedley, M Milosevic - Seminars in nuclear medicine, 2015 - Elsevier
Hypoxia is present to some extent in most solid malignant human cancers because of an
imbalance between the limited oxygen delivery capacity of the abnormal vasculature and …
imbalance between the limited oxygen delivery capacity of the abnormal vasculature and …
Interfering with tumor hypoxia for radiotherapy optimization
Hypoxia in solid tumors is an important predictor of treatment resistance and poor clinical
outcome. The significance of hypoxia in the development of resistance to radiotherapy has …
outcome. The significance of hypoxia in the development of resistance to radiotherapy has …