Regions of reduced oxygenation (hypoxia) are a characteristic feature of virtually all animal
and human solid tumours. Numerous preclinical studies, both in vitro and in vivo, have …

Tumor hypoxia or a reduction of the tissue oxygen tension is a key microenvironmental
factor for tumor progression and treatment resistance in solid tumors. Because hypoxic …

Since the initial observations made at the beginning of the last century, it has been
established that solid tumors contain regions of low oxygenation (hypoxia). Tumor cells can …

Highlights• Oxygen fixes DNA damage by free radicals and cells are 2–3 times more
radioresistant to sparsely ionising radiation when irradiated in the absence of oxygen.• OER …

The results from many studies indicate that most solid tumors, regardless of site of origin,
contain hypoxic regions. Experimental studies have demonstrated that, apart from the well …

Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to
an inadequate, and heterogeneous vascular network. It is associated with resistance to …

Tumor hypoxia has been considered to be a potential therapeutic problem because it
renders solid tumors more resistant to sparsely ionizing radiation (IR) and chemotherapeutic …

Tumor hypoxia influences the outcome of treatment with radiotherapy, chemotherapy and
even surgery, not only for the treatment of large bulky tumors with extensive necrosis, but …

Hypoxia is present to some extent in most solid malignant human cancers because of an
imbalance between the limited oxygen delivery capacity of the abnormal vasculature and …

Hypoxia in solid tumors is an important predictor of treatment resistance and poor clinical
outcome. The significance of hypoxia in the development of resistance to radiotherapy has …