Background Intravascular hemolysis is an intrinsic feature of severe malaria
pathophysiology but the pathogenic role of cell-free hemoglobin-mediated oxidative stress …

Background Hemolysis causes anemia in falciparum malaria, but its contribution to
microvascular pathology in severe malaria (SM) is not well characterized. In other hemolytic …

Plasmodium knowlesi occurs throughout Southeast Asia, and is the most common cause of
human malaria in Malaysia. Severe disease in humans is characterised by high parasite …

Malaria infection is known to cause severe hemolysis due to production of abnormal RBCs
and enhanced RBC destruction through apoptosis. Infected RBC lysis exposes uninfected …

In Ghana, uncomplicated malaria and sickle cell disease (SCD) is common, hence
comorbidity is not farfetched. However, the extent of oxidative stress and the array of clinical …

Plasmodium falciparum infections can cause severe malaria, but not every infected person
develops life-threatening complications. In particular, carriers of the structural …

Hemolytic anemia is one of the hallmarks of malaria and leads to an increase in oxidized
heme (hemin) within the plasma of infected individuals. While scavenger proteins sequester …

Reports indicate that Plasmodium infections influence methemoglobin levels. However,
findings have been inconclusive or have varied across different geographic and …

Severe anemia is an important contributor to mortality in children with severe malaria.
Anemia in malaria is a multi-factorial complication, since dyserythropoiesis, hemolysis and …

Background Acetaminophen inhibits cell-free hemoglobin-induced lipid peroxidation and
improves renal function in severe falciparum malaria but has not been evaluated in other …