Role of IL-33 in inflammation and disease

AM Miller - Journal of inflammation, 2011 - Springer
Abstract Interleukin (IL)-33 is a new member of the IL-1 superfamily of cytokines that is
expressed by mainly stromal cells, such as epithelial and endothelial cells, and its …

Disease-associated functions of IL-33: the new kid in the IL-1 family

FY Liew, NI Pitman, IB McInnes - Nature Reviews Immunology, 2010 - nature.com
Abstract Interleukin-33 (IL-33), a newly described member of the IL-1 family, is expressed by
many cell types following pro-inflammatory stimulation and is thought to be released on cell …

Interleukin-33 (IL-33): A critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine

C Cayrol, JP Girard - Cytokine, 2022 - Elsevier
Abstract Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with
crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic …

Interleukin-33 in health and disease

FY Liew, JP Girard, HR Turnquist - Nature Reviews Immunology, 2016 - nature.com
Abstract Interleukin-33 (IL-33)—a member of the IL-1 family—was originally described as an
inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now …

Interleukin-33 biology with potential insights into human diseases

G Palmer, C Gabay - Nature Reviews Rheumatology, 2011 - nature.com
Abstract Interleukin (IL)-33 is a member of the IL-1 family of cytokines. IL-33 is a nuclear
protein that is also released into the extracellular space, and thus acts as a dual-function …

Targeting IL-33 in autoimmunity and inflammation

TC Theoharides, AI Petra, A Taracanova… - … of Pharmacology and …, 2015 - ASPET
Interleukin-33 (IL-33) belongs to the IL-1 family of cytokines. Whereas IL-1 is processed and
released by live immune cells in response to infection or other triggers, IL-33 is mostly …

A network map of IL-33 signaling pathway

SM Pinto, Y Subbannayya, DAB Rex, R Raju… - Journal of cell …, 2018 - Springer
Abstract Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that play a central
role in the regulation of immune responses. Its release from epithelial and endothelial cells …

IL-33 in rheumatic diseases

Y Dong, J Zhong, L Dong - Frontiers in Medicine, 2021 - frontiersin.org
Interleukin-33 (IL-33) is a nuclear factor mainly expressed in barrier epithelium, endothelial
cells, and fibroblast reticular cells. Some inflammatory cells also express IL-33 under certain …

The IL-33/ST2 axis: role in health and disease

M De la Fuente, TT MacDonald, MA Hermoso - Cytokine & growth factor …, 2015 - Elsevier
Abstract IL-33, an IL-1 family member, is expressed by many cell types and can regulate
gene transcription. IL-33 is released upon cell necrosis and the precursor form is …

Crucial and diverse role of the interleukin-33/ST2 axis in infectious diseases

O Rostan, MI Arshad, C Piquet-Pellorce… - Infection and …, 2015 - Am Soc Microbiol
ABSTRACT Interleukin-33 (IL-33) has now emerged as a cytokine with diverse and
pleiotropic functions in various infectious and inflammatory diseases. IL-33 is expressed by …