Toxicokinetics provides a powerful tool, which is not used sufficiently in the conduct and
interpretation of animal toxicity studies. In selecting doses for toxicity studies toxicokinetic …

The objective of this article is to present a multidisciplined approach in the design of
toxicological studies involving the areas of pharmaceutical sciences, drug metabolism, and …

The principles of pharmacokinetics apply to any environmental nonnutrient (xenobiotic), and
many of the biological processes involved in the absorption, distribution, and elimination …

A major challenge in the risk/benefit assessment of new chemical entities is the rational and
reliable extrapolation of preclinical (nonclinical) safety evaluation data from animals to …

Toxicokinetic analyses have become a routine component of preclinical toxicology studies
with pharmaceutical candidates. Evaluation of plasma and/or tissue samples from animals …

1. Toxicokinetics is defined as pharmacokinetic studies in animals during actual toxicity
studies or under conditions mimicking them (species, duration, dose level, etc.). 2 …

The objective of a toxicological study is to elucidate the untoward effects of a chemical,
qualitatively and, quantitatively. The ultimate goal to be realized from acquisition of this …

Pharmacokinetics has evolved into a highly interactive discipline in which the dispositional
characteristics of an administered drug are often compared to the time course of observed …

Drug development is a dynamic process requiring toxicokinetics to keep pace with the
progression and results of nonclinical and clinical studies. Toxicokinetics should thus be …

The objectives of toxicokinetic (TK) studies are to evaluate systemic exposure of the toxicity
species to drug and/or metabolite (s) and to relate exposure to dose level and toxicological …