Opioids such as morphine and oxycodone are analgesics frequently prescribed for the
treatment of moderate or severe pain. Unfortunately, these medications are associated with …

Although drugs are intended to be selective, at least some bind to several physiological
targets, explaining side effects and efficacy. Because many drug–target combinations exist …

Opioids have an important place in pharmacology. While their clinical use as analgesics is
fundamental in medicine, their use is constrained by their side-effects and abuse potential …

Mu-opioid receptor (µOR) agonists such as fentanyl have long been used for pain
management, but are considered a major public health concern owing to their adverse side …

Background Computer-aided drug discovery (CADD) has become an essential part of
several projects in different settings and research environments. CADD has largely …

G protein‐coupled receptors (GPCRs) form a large protein family that plays an important role
in many physiological and pathophysiological processes. However, the central role that the …

Dopamine receptors are implicated in the pathogenesis and treatment of nearly every
neuropsychiatric disorder. Although thousands of drugs interact with these receptors, our …

Development of analgesic agents for the treatment of severe pain requires the identification
of compounds that are devoid of opioid receptor liabilities. A potent (inhibition constant= 37 …

Opium is one of the world's oldest drugs, and its derivatives morphine and codeine are
among the most used clinical drugs to relieve severe pain. These prototypical opioids …

STRONGHOLDS FOR DRUG DISCOVERY Historically, natural products (NPs) have played
a key role in the development of chemotherapy, 1, 2 and to this very day numerous marketed …