The understanding of Parkinson's disease (PD) classically revolves around dopamine
depletion within the striatum. However, PD is a multi-systemic disease in which extra …

Parkinson's disease (PD) is a common, late-onset neurodegenerative disorder that shows
progressive extrapyramidal motor disorders (eg, bradykinesia, resting tremors, muscle …

Although the cardinal manifestations of Parkinson's disease (PD) are attributed to a decline
in dopamine levels in the striatum, a breadth of non-motor features and treatment-related …

Thirty Parkinson's disease (PD) patients were divided into three equal groups according to
their disease duration while 10 normal healthy volunteers matched for age and sex served …

l-DOPA remains the most effective treatment for Parkinson's disease (PD). However, long-
term administration of l-DOPA is compromised by complications, particularly dyskinesia …

Parkinson's disease (PD) has long been seen as a disorder caused by degeneration of the
dopaminergic system, leading to the classic motor manifestations of the disease. However …

Interest in serotonergic involvement in Parkinson's disease (PD) has focussed recently on
the possibility that the remaining serotonin neurons innervating striatum (caudate and …

The serotonergic nervous system plays crucial roles in regulating psycho-emotional,
cognitive, sensori-motor and autonomic functions. It is now known that multiple serotonin (5 …

Parkinson's disease, the most common neurological disorder in the elderly, is characterized
by progressive extrapyramidal motor dysfunction including resting tremors, muscle rigidity …

While Parkinson's disease is undoubtedly a disorder with a primary pathology of dopamine
neuronal loss, that loss of dopamine and subsequent dopamine replacement therapy leads …