[HTML][HTML] Incorporating distant sequence features and radial basis function networks to identify ubiquitin conjugation sites
Ubiquitin (Ub) is a small protein that consists of 76 amino acids about 8.5 kDa. In ubiquitin
conjugation, the ubiquitin is majorly conjugated on the lysine residue of protein by Ub …
conjugation, the ubiquitin is majorly conjugated on the lysine residue of protein by Ub …
[HTML][HTML] UbiSite: incorporating two-layered machine learning method with substrate motifs to predict ubiquitin-conjugation site on lysines
CH Huang, MG Su, HJ Kao, JH Jhong, SL Weng… - BMC systems …, 2016 - Springer
Background The conjugation of ubiquitin to a substrate protein (protein ubiquitylation), which
involves a sequential process–E1 activation, E2 conjugation and E3 ligation, is crucial to the …
involves a sequential process–E1 activation, E2 conjugation and E3 ligation, is crucial to the …
Incorporating key position and amino acid residue features to identify general and species-specific Ubiquitin conjugation sites
X Chen, JD Qiu, SP Shi, SB Suo, SY Huang… - …, 2013 - academic.oup.com
Motivation: Systematic dissection of the ubiquitylation proteome is emerging as an
appealing but challenging research topic because of the significant roles ubiquitylation play …
appealing but challenging research topic because of the significant roles ubiquitylation play …
GPS-Uber: a hybrid-learning framework for prediction of general and E3-specific lysine ubiquitination sites
As an important post-translational modification, lysine ubiquitination participates in
numerous biological processes and is involved in human diseases, whereas the site …
numerous biological processes and is involved in human diseases, whereas the site …
[HTML][HTML] Characterization and identification of ubiquitin conjugation sites with E3 ligase recognition specificities
Background In eukaryotes, ubiquitin-conjugation is an important mechanism underlying
proteasome-mediated degradation of proteins, and as such, plays an essential role in the …
proteasome-mediated degradation of proteins, and as such, plays an essential role in the …
A new scheme to characterize and identify protein ubiquitination sites
Protein ubiquitination, involving the conjugation of ubiquitin on lysine residue, serves as an
important modulator of many cellular functions in eukaryotes. Recent advancements in …
important modulator of many cellular functions in eukaryotes. Recent advancements in …
hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties
Z Chen, Y Zhou, J Song, Z Zhang - … et Biophysica Acta (BBA)-Proteins and …, 2013 - Elsevier
As one of the most common post-translational modifications, ubiquitination regulates the
quantity and function of a variety of proteins. Experimental and clinical investigations have …
quantity and function of a variety of proteins. Experimental and clinical investigations have …
[HTML][HTML] Prediction of Ubiquitination Sites by Using the Composition of k-Spaced Amino Acid Pairs
As one of the most important reversible protein post-translation modifications, ubiquitination
has been reported to be involved in lots of biological processes and closely implicated with …
has been reported to be involved in lots of biological processes and closely implicated with …
[HTML][HTML] Computational identification of ubiquitylation sites from protein sequences
Background Ubiquitylation plays an important role in regulating protein functions. Recently,
experimental methods were developed toward effective identification of ubiquitylation sites …
experimental methods were developed toward effective identification of ubiquitylation sites …
Prediction of protein ubiquitination sites via multi-view features based on eXtreme gradient boosting classifier
Y Liu, S Jin, L Song, Y Han, B Yu - Journal of Molecular Graphics and …, 2021 - Elsevier
Ubiquitination is a common and reversible post-translational protein modification that
regulates apoptosis and plays an important role in protein degradation and cell diseases …
regulates apoptosis and plays an important role in protein degradation and cell diseases …