Increased expression of the interferon-inducible double-stranded RNA-activated protein
kinase (PKR) has been reported in acute leukemia and solid tumors, but the role of PKR has …

The double‐stranded RNA‐dependent kinase PKR has been described for many years as
strictly a pro‐apoptotic kinase. Recent data suggest that the main purpose of this kinase is …

The double-stranded RNA-dependent protein kinase PKR plays a central role in IFN-
mediated antiviral response. The ability of PKR mutants to transform rodent fibroblasts led to …

RNA-dependent protein kinase is an interferon-induced, double-stranded (ds), RNA-
activated serine/threonine protein kinase involved in the eukaryotic response to viral …

Purpose: Activation of the double-stranded RNA-activated protein kinase (PKR) leads to the
induction of various pathways including the down-regulation of translation through …

Reduced expression and activity of the proapoptotic, double-stranded RNA-dependent
protein kinase, PKR (protein kinase R) is observed in breast, lung and various leukemias …

Protein kinase R (PKR) is an interferon (IFN)-inducible, double-stranded RNA-activated
kinase that initiates apoptosis in response to cellular stress. To determine the role of PKR in …

Double‐stranded (ds) RNA‐dependent protein kinase (PKR) is a ubiquitously expressed
serine/threonine protein kinase. It was initially identified as an innate immune antiviral …

Abstract The interferon (IFN)-induced, double stranded RNA (dsRNA)-activated
serine/threonine kinase, PKR, is a potent negative regulator of cell growth when …

A number of cancers possess constitutive activity of the dsRNA-dependent kinase, PKR.
Inhibition of PKR in these cancers leads to tumor cell death. We recently reported the …