Simple Summary Chronic inflammation is known to drive cancer initiation and progression in
the liver and other organs. In different genetic mouse models, the role of the pro …

Abstract TGF-β-activated kinase 1 (TAK1 or MAP3K7) is an intracellular hub molecule that
regulates both nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) …

TGF-β–activated kinase 1 (TAK1) is a MAP3K family member that activates NF-κB and JNK
via Toll-like receptors and the receptors for IL-1, TNF-α, and TGF-β. Because the TAK1 …

Abstract TGF-β-activated kinase 1 (TAK1) is a MAP3K family member that activates NF-κB
and JNK via Toll-like receptors and the receptors for IL-1, TNF-α, and TGF-β. Because the …

Transforming growth factor beta-activated kinase 1 (TAK1) has been implicated for its role in
inflammatory signaling and as an important mediator of cellular apoptosis and necroptosis in …

Chronic insult and persistent injury can cause liver inflammation, fibrosis, and
carcinogenesis; it can also be associated with metabolic disorders. Identification of critical …

The MAP3-kinase TGF-β-activated kinase 1 (TAK1) critically modulates innate and adaptive
immune responses and connects cytokine stimulation with activation of inflammatory …

TAK1 suppresses a NEMO-dependent but NF-kappab-independent pathway to liver cancer.
Kira Bettermann, Mihael Vucur, Johannes Haybaeck, Christiane Koppe, Jörn Janssen, Felix …

Background & Aims Identifying novel and actionable targets in hepatocellular carcinoma
(HCC) remains an unmet medical need. TAK1 was originally identified as a transforming …

BACKGROUND & AIMS: Transforming growth factor (TGF)-β–activated kinase 1 (TAK1) is
activated in different cytokine signaling pathways. Deletion of Tak1 from hepatocytes results …