Transforming growth factor-β activated kinase 1 (Tak1) is activated in hepatocellular carcinoma, mediates tumor progression, and predicts unfavorable outcome

DA Ridder, LL Urbansky, HR Witzel, M Schindeldecker… - Cancers, 2022 - mdpi.com
Simple Summary Chronic inflammation is known to drive cancer initiation and progression in
the liver and other organs. In different genetic mouse models, the role of the pro …

TAK1 regulates hepatic cell survival and carcinogenesis

YS Roh, J Song, E Seki - Journal of gastroenterology, 2014 - Springer
Abstract TGF-β-activated kinase 1 (TAK1 or MAP3K7) is an intracellular hub molecule that
regulates both nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) …

Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis

S Inokuchi, T Aoyama, K Miura… - Proceedings of the …, 2010 - National Acad Sciences
TGF-β–activated kinase 1 (TAK1) is a MAP3K family member that activates NF-κB and JNK
via Toll-like receptors and the receptors for IL-1, TNF-α, and TGF-β. Because the TAK1 …

[PDF][PDF] The MAP3K TAK1: a chock block to liver cancer formation

Y Malato, H Willenbring - Hepatology, 2010 - Wiley Online Library
Abstract TGF-β-activated kinase 1 (TAK1) is a MAP3K family member that activates NF-κB
and JNK via Toll-like receptors and the receptors for IL-1, TNF-α, and TGF-β. Because the …

[HTML][HTML] TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades

SA Scarneo, KW Yang, JR Roques, A Dai… - Oncotarget, 2020 - ncbi.nlm.nih.gov
Transforming growth factor beta-activated kinase 1 (TAK1) has been implicated for its role in
inflammatory signaling and as an important mediator of cellular apoptosis and necroptosis in …

[HTML][HTML] TAK1: a molecular link between liver inflammation, fibrosis, steatosis, and carcinogenesis

W Wang, W Gao, Q Zhu, A Alasbahi, E Seki… - Frontiers in cell and …, 2021 - frontiersin.org
Chronic insult and persistent injury can cause liver inflammation, fibrosis, and
carcinogenesis; it can also be associated with metabolic disorders. Identification of critical …

[PDF][PDF] TAK1 suppresses a NEMO-dependent but NF-κB-independent pathway to liver cancer

K Bettermann, M Vucur, J Haybaeck, C Koppe… - Cancer cell, 2010 - cell.com
The MAP3-kinase TGF-β-activated kinase 1 (TAK1) critically modulates innate and adaptive
immune responses and connects cytokine stimulation with activation of inflammatory …

[HTML][HTML] TAK1: Another mesh in the NF-κB–JNK controlled network causing hepatocellular carcinoma

FR Greten - Journal of hepatology, 2011 - Elsevier
TAK1 suppresses a NEMO-dependent but NF-kappab-independent pathway to liver cancer.
Kira Bettermann, Mihael Vucur, Johannes Haybaeck, Christiane Koppe, Jörn Janssen, Felix …

[HTML][HTML] TAK1 is a novel target in hepatocellular carcinoma and contributes to sorafenib resistance

S Xia, L Ji, L Tao, Y Pan, Z Lin, Z Wan, H Pan… - Cellular and molecular …, 2021 - Elsevier
Background & Aims Identifying novel and actionable targets in hepatocellular carcinoma
(HCC) remains an unmet medical need. TAK1 was originally identified as a transforming …

Transforming growth factor–β signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1

L Yang, S Inokuchi, YS Roh, J Song, R Loomba… - Gastroenterology, 2013 - Elsevier
BACKGROUND & AIMS: Transforming growth factor (TGF)-β–activated kinase 1 (TAK1) is
activated in different cytokine signaling pathways. Deletion of Tak1 from hepatocytes results …