Introduction Abnormal glycolytic metabolism contributes to joint inflammation and
destruction in rheumatoid arthritis (RA). We examine the expression and function of …

Thymoquinone, an active ingredient isolated from Nigella sativa, has been reported to have
anti-inflammatory effects. However, the anti-inflammatory effect of thymoquinone on IL-1β …

Background Osteoarthritis (OA), the most common joint disorder, is characterized by a
progressive degradation of articular cartilage. Increasing evidence suggests that OA is …

We previously revealed that the overexpression of synovial aquaporin 1 (AQP1) aggravated
collagen-induced arthritis (CIA) in rats via regulating β-catenin signaling. This study was to …

Objectives Glycogen synthase kinase (GSK)-3β, a serine/threonine protein kinase, has been
implicated as a regulator of the inflammatory response. This study was performed to …

Introduction Nuclear factor-κB (NF-κB) transcription factor regulates several cell signaling
pathways, such as differentiation and inflammation, which are both altered in osteoarthritis …

The purpose of the experiment was to explore the effect of Ganoderic acid A (GAA) on
adjuvant-induced arthritis in rats. In this study, the rat model of collagen-induced rheumatoid …

Increasing evidence indicates that osteoarthritis (OA) is a musculoskeletal disease affecting
the whole joint, including both cartilage and subchondral bone. Reactive oxygen species …

Purpose The pathogenesis of osteoarthritis (OA) is characterized by joint degeneration. The
pro-inflammatory cytokine interleukin (IL)-1β plays a vital role in the pathogenesis of OA by …

Ginsenoside compound K (GCK) has been previously reported to be a potent antiarthritic
and bone‑protective agent. Therefore, the present study aimed to explore the potential …