Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis using omics analysis

H Pan, Y Zheng, Z Liu, Z Yuan, R Ren, H Zhou… - Frontiers of …, 2019 - Springer
Traditional Chinese medicine (TCM) formulas have attracted increasing attention worldwide
in the past few years for treating complex disease including rheumatoid arthritis. However …

[HTML][HTML] Evaluation of the anti-inflammatory actions of various functional food materials including glucosamine on synovial cells

Y Yamagishi, A Someya, K Imai… - Molecular …, 2017 - spandidos-publications.com
The anti-inflammatory actions of glucosamine (GlcN) on arthritic disorders involve the
suppression of inflammatory mediator production from synovial cells. GlcN has also been …

PGK1, a glucose metabolism enzyme, may play an important role in rheumatoid arthritis

Y Zhao, X Yan, X Li, Y Zheng, S Li, X Chang - Inflammation Research, 2016 - Springer
Background Some studies have indicated that glucose metabolism plays an important role
in the pathogenesis of rheumatoid arthritis (RA). This study aimed to find the novel genes …

The Anti‐Arthritic and Immune‐Modulatory Effects of NHAG: A Novel Glucosamine Analogue in Adjuvant‐Induced Arthritis

SUA Shah, H Jawed, SI Awan, S Anjum… - BioMed research …, 2013 - Wiley Online Library
Rheumatoid arthritis (RA) is potentially devastating condition which lacks good treatment
options. Pro‐inflammatory cytokines interleukin‐1beta (IL‐1β), tumor necrosis factor‐alpha …

Chymotrypsin attenuates adjuvant-induced arthritis by downregulating TLR4, NF-κB, MMP-1, TNF-α, IL-1β, and IL-6 expression in Sprague–Dawley rats

J Li, L Wang, G Zeng, H Li, J Luo, Q Tian… - Immunopharmacology …, 2022 - Taylor & Francis
Objective Rheumatoid arthritis (RA) is mainly characterized by synovial hyperplasia,
angiogenesis, inflammatory cells infiltration. Chymotrypsin is a proteolytic enzyme with anti …

Glycyrrhizin inhibits osteoarthritis development through suppressing the PI3K/AKT/NF-κB signaling pathway in vivo and in vitro

RH Jiang, JJ Xu, DC Zhu, JF Li, CX Zhang, N Lin… - Food & function, 2020 - pubs.rsc.org
Osteoarthritis (OA) is a serious and frequently occurring disease in the elderly, characterized
by cartilage degeneration and proliferation of bone structure. Glycyrrhizin, a compound …

[HTML][HTML] The physiological metabolite α-ketoglutarate ameliorates osteoarthritis by regulating mitophagy and oxidative stress

L Liu, W Zhang, T Liu, Y Tan, C Chen, J Zhao, H Geng… - Redox biology, 2023 - Elsevier
Osteoarthritis (OA) is an age-related metabolic disease. Low-grade inflammation and
oxidative stress are the last common pathway of OA. α-ketoglutarate (α-KG) is an essential …

[HTML][HTML] Glutamine exerts a protective effect on osteoarthritis development by inhibiting the Jun N-terminal kinase and nuclear factor kappa-B signaling pathways

L Zhong, L Cao, R Song, XF Yang, JL Li, HT Yang… - Scientific Reports, 2022 - nature.com
Strategies for treating osteoarthritis (OA) have become a research focus because an
effective treatment for OA is unavailable. The objective of this study was to explore the …

[HTML][HTML] TNF‑α increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate …

H Li, S Xie, Y Qi, H Li, R Zhang… - Experimental and …, 2018 - spandidos-publications.com
Osteoarthritis is a degenerative disease that often causes patients to experience joint pain
and deformity. It has been demonstrated that tumor necrosis factor (TNF)‑α is associated …

Stachydrine attenuates IL-1β-induced inflammatory response in osteoarthritis chondrocytes through the NF-κB signaling pathway

H Wu, M Zhang, W Li, S Zhu, D Zhang - Chemico-biological interactions, 2020 - Elsevier
Osteoarthritis (OA) is a common degenerative joint disease that is closely associated with
inflammation. Stachydrine (STA) is a bioactive alkaloid with anti-inflammatory activity …