[HTML][HTML] PI3K/Akt inhibitor partly decreases TNF-α-induced activation of fibroblast-like synoviocytes in osteoarthritis
S Liu, C Cao, Y Zhang, G Liu, W Ren, Y Ye… - Journal of orthopaedic …, 2019 - Springer
Abstract Background The Cadherin-11 and PI3K/Akt pathway are increasingly recognized
as the potential therapeutic target of osteoarthritis (OA) synovitis. The study aimed to …
as the potential therapeutic target of osteoarthritis (OA) synovitis. The study aimed to …
Therapeutic effects of kefir peptides on adjuvant-induced arthritis in rats through anti-inflammation and downregulation of matrix metalloproteinases
Aims Rheumatoid arthritis (RA) is a chronic autoimmune disease. Its pathological features
are synovial inflammation, bone erosion, and joint structural damages. Our previous studies …
are synovial inflammation, bone erosion, and joint structural damages. Our previous studies …
c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 is a critical regulator for arthritis progression by meditating inflammation in mice …
H Guo, H Lei, BG Zhang, ZC Xu, C Dong… - International …, 2020 - Elsevier
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease. However, the
pathogenesis of RA is not fully understood. Here, we reported that c-Jun NH2-terminal …
pathogenesis of RA is not fully understood. Here, we reported that c-Jun NH2-terminal …
Inhibition of hedgehog signal pathway by cyclopamine attenuates inflammation and articular cartilage damage in rats with adjuvant-induced arthritis
R Li, L Cai, J Ding, C Hu, T Wu… - Journal of Pharmacy and …, 2015 - academic.oup.com
Objectives We investigated whether inhibition of hedgehog (Hh) signal by cyclopamine
attenuated inflammation and cartilage damage in adjuvant-induced arthritis (AIA) rats …
attenuated inflammation and cartilage damage in adjuvant-induced arthritis (AIA) rats …
Chitosan oligosaccharide suppresses synovial inflammation via AMPK activation: An in vitro and in vivo study
W Kunanusornchai, B Witoonpanich… - Pharmacological …, 2016 - Elsevier
Synovial inflammation plays an important role in the early pathogenesis of osteoarthritis
(OA). Chitosan oligosaccharide (COS) has been shown to activate AMPK and suppress …
(OA). Chitosan oligosaccharide (COS) has been shown to activate AMPK and suppress …
Combination therapy of ginsenoside compound K and methotrexate was efficient in elimination of anaemia and reduction of disease activity in adjuvant-induced …
J Chen, W Wang, M Jiang, M Yang… - Pharmaceutical Biology, 2020 - Taylor & Francis
Abstract Context Ginsenoside compound K (CK) has anti-inflammatory, immunoregulatory,
and myelosuppressive protective effects. Methotrexate (MTX) is widely used in combination …
and myelosuppressive protective effects. Methotrexate (MTX) is widely used in combination …
[HTML][HTML] Glucosamine inhibits IL-1β-induced NFκB activation in human osteoarthritic chondrocytes
R Largo, MA Alvarez-Soria, I Dıez-Ortego… - Osteoarthritis and …, 2003 - Elsevier
Objective: Glucosamine sulfate (GS) is a commonly used drug for the treatment of
osteoarthritis. The mechanism of the action of this drug does, however, remain to be …
osteoarthritis. The mechanism of the action of this drug does, however, remain to be …
Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis
JF Xue, ZM Shi, J Zou, XL Li - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Objective This study aims to explore the relationship between PI3K/AKT/mTOR signaling
pathway and autophagy of articular chondrocytes in rats with osteoarthritis (OA). Methods …
pathway and autophagy of articular chondrocytes in rats with osteoarthritis (OA). Methods …
[HTML][HTML] Compound K inhibits interleukin-1β-induced expression of inflammatory mediators and matrix metalloproteinases by inhibiting mitogen-activated protein …
Objective. This study examined the anti-inflammatory and chondroprotective effects of
compound K (CK), a ginsenoside metabolite, on chondrocytes from osteoarthritis (OA) …
compound K (CK), a ginsenoside metabolite, on chondrocytes from osteoarthritis (OA) …
[HTML][HTML] Ketogenic diet ameliorates inflammation by inhibiting the NLRP3 inflammasome in osteoarthritis
G Kong, J Wang, R Li, Z Huang, L Wang - Arthritis Research & Therapy, 2022 - Springer
Background The nucleotide-binding domain, leucine-rich repeat, and pyrin domain-
containing protein 3 (NLRP3) inflammasome has been reported to be involved in the …
containing protein 3 (NLRP3) inflammasome has been reported to be involved in the …