Objective: Osteoarthritis (OA) is one of the most common chronic diseases, which is
characterized by cartilage degeneration, subchondral osteosclerosis, and synovitis …

Background CD38+ NK cells are overabundant in rheumatoid arthritis (RA). Cyanidin-3-O-
glucoside (C3G) is an inhibitor of CD38. This study investigated the pathogenic role of …

Articular cartilage injury or defect is a common disease and is mainly characterized by
cartilage degradation because of chondrocyte inflammation. By now, there are no effective …

Sinapic acid (SA) was reported to protect against inflammation in various types of diseases.
However, the role of SA in rheumatoid arthritis remains unclear. This study was designed to …

Ginsenoside metabolite compound K (CK) is the degradation product of ginsenosides in the
intestine by bacteria and has many pharmacological activities including anti-inflammatory …

Background Synovial fibroblasts in rheumatoid arthritis (RAFLS) exhibit a pathological
aberration of glycolysis and glutaminolysis. Henceforth, we aimed to investigate if dual …

Background RAF and ERK pathways are known to be activated in human rheumatoid
arthritis (RA) fibroblast-like synoviocytes (FLS), which play an important role in the …

At present, the early phenomenon of inflammatory angiogenesis is rarely studied in
Rheumatoid arthritis (RA). Previous research found that PEG-HM-3, an integrin inhibitor …

Increasing evidence has shown that NLRP3 inflammasome activation participates in chronic
aseptic inflammation and is related to tissue fibrosis. Our last study also revealed the vital …

Context: Osteoarthritis (OA) is a degenerative joint disease with damage to the articular
cartilage. Active production of inflammatory cytokine/chemokine and matrix …