Abstract Existing in Ranunculaceae Aconitum and tomato, with the chemical name 1‑
phydroxybenzyl‑1, 2, 3, 4‑tetrahy‑droisoquinoline, higenamine is widely distributed in China …

At present, the early phenomenon of inflammatory angiogenesis is rarely studied in
Rheumatoid arthritis (RA). Previous research found that PEG-HM-3, an integrin inhibitor …

The purpose of this study was to investigate the possible involvement of synovium in
cartilage destruction in osteoarthritis (OA) patients. Using human primary synovial fibroblasts …

The purpose of the present study was to elucidate the possible signal transduction pathway
involved in the underlying mechanism of glucosamine (GLN)'s influence on the gene …

Background Osteoarthritis (OA) treatment aims to improve inflammation and delay cartilage
degeneration. However, there is no effective strategy presently available. Ononin, a …

Objective We examined the effects of ZSTK474, a phosphatidylinositol 3-kinase (PI3K)
inhibitor, on adjuvant-induced arthritis (AIA). Methods AIA was induced in Lewis rats by …

Objective The present study was designed to explore the potential anti-inflammatory and
anti-arthritic effects of ellagic acid (EA) in collagen-induced arthritis (CIA). Methods CIA rats …

Both hyaluronic acid (HA) and cyclooxygenase-2 (COX-2) inhibitors are used in clinical
practice in the treatment of osteoarthritis. There have been no reports regarding cross-talk …

Previous studies demonstrated that penta-acetyl geniposide ((Ac) 5 GP, an acetylated
derivative of geniposide) exhibited better pharmacological functions than geniposide. This …

Osteoarthritis (OA) is driven by chronic low-grade inflammation and subsequent cartilage
degradation. OA is the most prevalent degenerative joint disease worldwide, and its …