High mobility group box 1 (HMGB1) is an important downstream product of pyroptosis in
macrophages, and it serves a vital role in numerous inflammatory diseases. Previous …

There is growing evidence that synovial tissue affects osteoblasts although the mechanisms
behind the aberrant bone metabolism in rheumatoid arthritis (RA) are unclear. The aim of …

The purpose of this research was to evaluate the therapeutic effects of gentiopicroside
(GPS) on adjuvant-induced arthritis (AA) rats. Rats were injected with complete Freund's …

Osteoarthritis is a type of joint disease that may lead to other joint diseases. Previous
research has demonstrated that tumor necrosis factor (TNF)‑α is associated with …

Background and objective: Mounting studies have illustrated an important role of autophagy
in various diseases, but few studies have reported its contribution to rheumatoid arthritis …

Background Genkwanin is a flavone isolated from the traditional Chinese herb Daphne
genkwa. Our previous work proved that four flavonoids (including genkwanin) isolated from …

Purpose Umbelliferone (Umb), a member of coumarin family, is found in many plants and is
a promising molecule with potential anti-inflammatory, anti-oxidative, and anti-tumor …

Objective Nitidine chloride (NC), a natural small molecular compound from traditional
Chinese herbal medicine zanthoxylum nitidum, has been shown to exhibit anti-tumor effect …

Pain is the main symptom of osteoarthritis, which severely reduces the patients' quality of
life. Stimulated neuroinflammation and elevated mitochondrial oxidative stress are …

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease. The imbalance of
T helper type 1 (Th1) and Th2 immune responses contributes to the pathogenesis of this …