Interactions of Aspergillus fumigatus with endothelial cells: internalization, injury, and stimulation of tissue factor activity

LML Bezerra, SG Filler - Blood, 2004 - ashpublications.org
Invasive aspergillosis causes significant mortality among patients with hematologic
malignancies. This infection is characterized by vascular invasion and thrombosis. To study …

Interactions of Aspergillus fumigatus with vascular endothelial cells

Y Kamai, LY Chiang, LM Lopes Bezerra… - Medical …, 2006 - academic.oup.com
Invasive aspergillosis is characterized by two different types of angioinvasion. During
pulmonary aspergillosis, hyphae are initially outside of the pulmonary vasculature and they …

Aspergillus fumigatus Stimulates Leukocyte Adhesion Molecules and Cytokine Production by Endothelial Cells In Vitro and during Invasive Pulmonary Disease

LY Chiang, DC Sheppard, FN Gravelat… - Infection and …, 2008 - Am Soc Microbiol
Invasive aspergillosis is characterized by hyphal invasion of the blood vessels, which
contributes to the pathogenesis of this disease. During this angioinvasion, Aspergillus …

Polarized response of endothelial cells to invasion by Aspergillus fumigatus

Y Kamai, AS Lossinsky, H Liu… - Cellular …, 2009 - Wiley Online Library
Hyphal invasion of blood vessels is a prominent feature of invasive aspergillosis. During
invasive pulmonary aspergillosis, Aspergillus fumigatus hyphae invade the abluminal …

Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites

R Ben-Ami, RE Lewis, K Leventakos… - Blood, The Journal …, 2009 - ashpublications.org
In susceptible hosts, angioinvasion by Aspergillus fumigatus triggers thrombosis, hypoxia,
and proinflammatory cytokine release, all of which are stimuli for angiogenesis. We sought …

Identification of genes of Aspergillus fumigatus up-regulated during growth on endothelial cells

JC Rhodes, BG Oliver, DS Askew… - Medical …, 2001 - academic.oup.com
Aspergillus fumigatus is an important opportunistic fungal pathogen that can cause acute
invasive disease in neutropenic hosts. Invasive aspergillosis is being diagnosed with …

Fungal invasion of normally non-phagocytic host cells

SG Filler, DC Sheppard - PLoS pathogens, 2006 - journals.plos.org
Many fungi that cause invasive disease invade host epithelial cells during mucosal and
respiratory infection, and subsequently invade endothelial cells during hematogenous …

Aspergillus fumigatus Activates Thrombocytes by Secretion of Soluble Compounds

C Speth, M Hagleitner, HW Ott… - The Journal of …, 2013 - academic.oup.com
During invasive aspergillosis, platelets might be involved in immune defense, but they also
might contribute to the pathology of the disease. We tested the hypothesis that Aspergillus …

Enemy of the (immunosuppressed) state: an update on the pathogenesis of Aspergillus fumigatus infection

R Ben‐Ami, RE Lewis… - British journal of …, 2010 - Wiley Online Library
Aspergillus fumigatus is an opportunistic filamentous fungus that is currently the most
frequent cause of invasive fungal disease in immunosuppressed individuals. Recent …

Intracellular and extracellular growth of Aspergillus fumigatus

JA Wasylnka, AHT Hissen, ANC Wan… - Medical mycology, 2005 - Taylor & Francis
Aspergillus fumigatus is a filamentous fungus that can cause a life-threatening systemic
mycosis in immunocompromised patients. We have studied the growth of A. fumigatus inside …