The early stages of dimethylnitrosamine (CAS: 62-75-9)-induced liver cancer and the effect
of administration of phenobarbital (CAS: 50-06-6) after dimethylnitrosamine were studied in …

A single dose of 15 mg/kg dimethylnitrosamine is an initiator of hepatic tumour formation in
rats but does not produce tumours without further treatment. Subsequent promotion by Na …

The dose-response relationship was determined in rats for the enhancement by
phenobarbital of diethylnitrosamine (DENA)-initiated neoplastic nodules and hepatocellular …

Sequential feeding of various dose levels of phenobarbital (PB) after diethylnitrosamine
(DENA) administration revealed that the enhancing effect of PB on hepatocarcinogenesis …

Administration of 40 ppm diethylnitrosamine (DENA) in the drinking water for 10 weeks to
male Fischer rats led to hepatocellular carcinoma in 100%, with metastasis to the lung in …

Diethylnitrosamine (DENA) hepatocarcinogenesis was enhanced by sequential exposure
with polychlorinated biphenyls (PCBs) and with phenobarbital. This was shown by the …

The effects of phenobarbital (PB) and amobarbital (AB) on the rate of development of
hepatocarcinogenesis induced by N-nitrosodiethylamine (DEN) were studied in mice …

Materials and Methods Two hundred male Wistar rats, 28 days old, were used.
Phenobarbital sodium, DDT, and PCB (Kanechlor 500) were used as tumor enhancers after …

A single dose of 15 mg/kg dimethylnitrosamine given to rats at the time of switch from low to
high protein diet is an effective initiator of hepatic tumour formation. With phenobarbitone as …

MATERIALS AND METHODS Inbred DDD strain mice were isolated from dd mice and
established in 1962.7) The inbred DDD strain mice used in this study were obtained from the …