Genomic signatures in T-cell lymphoma: How can these improve precision in diagnosis and inform prognosis?

J Iqbal, R Wilcox, H Naushad, J Rohr, TB Heavican… - Blood reviews, 2016 - Elsevier
The novel genetic information gained from genome-wide high throughput techniques has
greatly improved our understanding of peripheral T-cell lymphoma (PTCL). PTCL consists of …

[HTML][HTML] Genomic insights into the pathogenesis of Epstein–Barr virus-associated diffuse large B-cell lymphoma by whole-genome and targeted amplicon sequencing

N Gebauer, A Künstner, J Ketzer, HM Witte… - Blood cancer …, 2021 - nature.com
Abstract Epstein–Barr virus (EBV)-associated diffuse large B-cell lymphoma not otherwise
specified (DLBCL NOS) constitute a distinct clinicopathological entity in the current World …

[HTML][HTML] Detection of new drivers of frequent B-cell lymphoid neoplasms using an integrated analysis of whole genomes

A Mosquera Orgueira, R Ferreiro Ferro, JÁ Díaz Arias… - PloS one, 2021 - journals.plos.org
B-cell lymphoproliferative disorders exhibit a diverse spectrum of diagnostic entities with
heterogeneous behaviour. Multiple efforts have focused on the determination of the genomic …

[HTML][HTML] Genomic characterization of pediatric T-cell acute lymphoblastic leukemia reveals novel recurrent driver mutations

JF Spinella, P Cassart, C Richer, V Saillour, M Ouimet… - Oncotarget, 2016 - ncbi.nlm.nih.gov
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with
variable prognosis. It represents 15% of diagnosed pediatric ALL cases and has a threefold …

[HTML][HTML] Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma

M Yamagishi, M Kubokawa, Y Kuze, A Suzuki… - Nature …, 2021 - nature.com
Subclonal genetic heterogeneity and their diverse gene expression impose serious
problems in understanding the behavior of cancers and contemplating therapeutic …

Proposal of a genetic classifier for risk group stratification in pediatric T-cell lymphoblastic lymphoma reveals differences from adult T-cell lymphoblastic leukemia

ST Balbach, O Makarova, BR Bonn, M Zimmermann… - Leukemia, 2016 - nature.com
T-cell lymphoblastic lymphoma (T-LBL) represents the second most common subtype of non-
Hodgkin's lymphoma (NHL) in children and adolescents. Current chemotherapy protocols …

Pediatric T-cell lymphoblastic lymphoma but not leukemia harbor TRB:: NOTCH1 fusions with unfavorable outcome

M Te Vrugt, JS Wessolowski, G Randau, A Alfert… - Blood …, 2024 - ashpublications.org
T-cell lymphoblastic lymphoma (T-LBL) and T-cell acute lymphoblastic leukemia (T-ALL)
have common and distinguishing clinical and molecular features. Molecular prognostic …

[HTML][HTML] Chromatin accessibility profiling to increase diagnostic accuracy and refine cell-of-Origin classification of mature T-cell lymphomas

E Julia, S Mareschal, A Chebel, C Golfier, TA Müller… - Blood, 2021 - Elsevier
Background: Mature T-cell lymphomas and leukemias (MTCL) are heterogeneous diseases
with dismal prognosis. Differentiating between the numerous entities requires specialized …

[HTML][HTML] Correlation of mutational landscape and survival outcome of peripheral T-cell lymphomas

Y Ye, N Ding, L Mi, Y Shi, W Liu, Y Song, S Shu… - … hematology & oncology, 2021 - Springer
Objective To explore the correlation of mutation landscape with clinical outcomes in patients
with peripheral T-cell lymphoma (PTCL). Methods We retrospectively analyzed the …

[HTML][HTML] Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma

P López-Nieva, P Fernández-Navarro… - Scientific Reports, 2019 - nature.com
Fusions transcripts have been proven to be strong drivers for neoplasia-associated
mutations, although their incidence in T-cell lymphoblastic lymphoma needs to be …