The IL6-174G/C Polymorphism Associated with High Levels of IL-6 Contributes to HCV Infection, but Is Not Related to HBV Infection, in the Amazon Region of Brazil

MAF Queiroz, AM Santiago, TCF Moura, ESG Amoras… - Viruses, 2022 - mdpi.com
The dysregulation of cytokine production can lead to an inefficient immune response,
promoting viral persistence that induces the progression of chronic viral hepatitis. The study …

Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymorphisms on serum levels of pro-inflammatory cytokines in …

AM Tarragô, AG da Costa, JPD Pimentel… - Human Immunology, 2014 - Elsevier
We investigated the association between hepatitis C virus (HCV) genotypes and host
cytokine gene polymorphisms and serum cytokine levels in patients with chronic hepatitis C …

Association of IL-10, IL-4, and IL-28B gene polymorphisms with spontaneous clearance of hepatitis C virus in a population from Rio de Janeiro

JA Ramos, R Silva, L Hoffmann, ALA Ramos… - BMC research …, 2012 - Springer
Background Cytokines play an important role in the regulation of the immune response. In
hepatitis C virus (HCV) infection, cytokine levels may influence the outcome of acute HCV …

The Genetic Profile and serum level of IL-8 are Associated with Chronic Hepatitis B and C Virus infection

ESG Amoras, WB de Brito, MAF Queiroz, SRSS Conde… - Biomolecules, 2021 - mdpi.com
The present study evaluated the IL8-251 A/T polymorphism in samples from 74 patients with
chronic hepatitis B (HBV), 100 patients with chronic hepatitis C (HCV), and 300 healthy …

Interleukin-6 Gene (-174 G> C) Polymorphisms in Patients with Chronic Hepatitis C Virus; A Case-Control Study

M Ahadi, M Khoshakhlagh, N Masoudifar… - Hepatitis …, 2024 - brieflands.com
Background: Recent studies have suggested that polymorphisms in the Interleukin (IL)-6
gene promoter might be linked to chronic hepatitis C virus (HCV) infection, potentially …

[HTML][HTML] Polymorphisms of IL-10 gene in patients infected with HCV under antiviral treatment in southern Brazil

NMO da Silva, FN Germano, BM Vidales-Braz… - Cytokine, 2015 - Elsevier
Abstract Interleukin-10 (IL-10) is a cytokine that plays an important role in the regulation of
the immune system. Gene polymorphisms of IL-10 have been associated with the different …

Association of cytokine gene polymorphisms with hepatitis C virus infection in a population from Rio de Janeiro, Brazil

GM Fabrício-Silva, BS Poschetzky… - Hepatic medicine …, 2015 - Taylor & Francis
Background The host immune response is an important indicator of the outcome of hepatitis
C virus (HCV) infection and disease progression. The aim of this study was to explore …

Combined analysis of interferon-γ and interleukin-10 gene polymorphisms and chronic hepatitis C severity

N Bouzgarrou, E Hassen, K Farhat, O Bahri… - Human immunology, 2009 - Elsevier
Today there is increasing evidence concerning the contribution of pro-/anti-inflammatory
cytokine balance and genetic factors in hepatitis C pathogenesis and interindividual …

Association of interleukin‐18 polymorphisms and plasma level with the outcome of chronic HCV infection

N Bouzgarrou, E Hassen, E Schvoerer… - Journal of medical …, 2008 - Wiley Online Library
Hepatitis C virus (HCV) infection is the main cause of chronic liver disease throughout the
world, and may progress to cirrhosis and hepatocellular carcinoma (HCC). Immunological …

[HTML][HTML] Analysis of polymorphisms in the interleukin 18 gene promotor (-137 G/C and-607 C/A) in patients infected with hepatitis C virus from the Brazilian Amazon

KN SANTOS, MKC ALMEIDA, AA Fecury… - Arquivos de …, 2015 - SciELO Brasil
Background The hepatitis C virus has been recognized as the leading cause of chronic liver
disease in the world. Host genetic factors have been implicated in the persistence of …