Study Objective. To determine the likelihood that antibiotic regimens achieve bactericidal
pharmacodynamic exposures against common nosocomial pathogens. Design …

Purpose Selected iv antimicrobials were evaluated against Pseudomonas aeruginosa
isolates collected from US hospitals to predict the likelihood of achieving maximal …

Objective: To compare the probability of achieving specific pharmacodynamic exposures of
commonly used intravenous antibiotics for the empirical treatment of nosocomial pneumonia …

The OPTAMA (Optimizing Pharmacodynamic Target Attainment using the MYSTIC
[Meropenem Yearly Susceptibility Test Information Collection] Antibiogram) Program …

Background: Treatment of infections caused by gram-negative bacilli is increasingly
challenging because of emerging resistance. Current surveillance data are informative, but …

Using minimum inhibitory concentration (MIC) data derived from a Chinese national
surveillance study and pharmacokinetic data collected in Chinese individuals, a 5000 …

The OPTAMA Program is intended to examine typical antimicrobial regimens used in the
treatment of common nosocomial pathogens and the likelihood of these regimens attaining …

Background: In the era of escalating antimicrobial resistance, the choice of effective empiric
antimicrobial therapy has become considerably more difficult. In an attempt to improve …

Background Increasing nosocomial pathogen resistance to available antimicrobial agents is
of growing concern. While higher MICs can diminish antimicrobial effectiveness, dose …

This study evaluated the pharmacodynamics of continuous infusion β-lactams against
pulmonary isolates of Gram-negative bacteria from patients managed in intensive care units …