Prioritization of candidate disease genes by enlarging the seed set and fusing information of the network topology and gene expression

SW Zhang, DD Shao, SY Zhang, YB Wang - Molecular BioSystems, 2014 - pubs.rsc.org
The identification of disease genes is very important not only to provide greater
understanding of gene function and cellular mechanisms which drive human disease, but …

Neighbor-favoring weight reinforcement to improve random walk-based disease gene prioritization

DH Le, YK Kwon - Computational biology and chemistry, 2013 - Elsevier
Background Finding candidate genes associated with a disease is an important issue in
biomedical research. Recently, many network-based methods have been proposed that …

Network-based disease gene prioritization based on protein–protein interaction networks

P Kaushal, S Singh - Network Modeling Analysis in Health Informatics and …, 2020 - Springer
The process to identify genes responsible for a disease is a complex task. The various
experimental techniques developed to identify disease-causing genes suffer from the …

Computational approaches for prioritizing candidate disease genes based on PPI networks

W Lan, J Wang, M Li, W Peng… - Tsinghua Science and …, 2015 - ieeexplore.ieee.org
With the continuing development and improvement of genome-wide techniques, a great
number of candidate genes are discovered. How to identify the most likely disease genes …

Prioritizing disease genes by using search engine algorithm

M Li, R Zheng, Q Li, J Wang, FX Wu… - Current …, 2016 - ingentaconnect.com
It is a fundamental challenge that identifying disease genes from a large number of
candidates for a specific disease. As the biological experiment-based methods are generally …

[HTML][HTML] Prioritization of potential candidate disease genes by topological similarity of protein–protein interaction network and phenotype data

J Luo, S Liang - Journal of biomedical informatics, 2015 - Elsevier
Identifying candidate disease genes is important to improve medical care. However, this task
is challenging in the post-genomic era. Several computational approaches have been …

[HTML][HTML] HybridRanker: integrating network topology and biomedical knowledge to prioritize cancer candidate genes

Z Razaghi-Moghadam, R Abdollahi, S Goliaei… - Journal of biomedical …, 2016 - Elsevier
In the past few years, many researches have been conducted on identifying and prioritizing
disease-related genes with the goal of achieving significant improvements in treatment and …

Using biomedical networks to prioritize gene–disease associations

JP Arrais, JL Oliveira - Open Access Bioinformatics, 2011 - Taylor & Francis
Understanding the genetic foundations of genetic diseases, such as cancer, Alzheimer
disease, or Huntington's disease, is critical to the development of new diagnostics and …

DiSNEP: a disease-specific gene network enhancement to improve prioritizing candidate disease genes

P Ruan, S Wang - Briefings in Bioinformatics, 2021 - academic.oup.com
Biological network-based strategies are useful in prioritizing genes associated with
diseases. Several comprehensive human gene networks such as STRING, GIANT and …

Recent approaches to the prioritization of candidate disease genes

NT Doncheva, T Kacprowski… - … : Systems Biology and …, 2012 - Wiley Online Library
Many efforts are still devoted to the discovery of genes involved with specific phenotypes, in
particular, diseases. High‐throughput techniques are thus applied frequently to detect …