[HTML][HTML] CD4+ T-cell responses mediate progressive neurodegeneration in experimental ischemic retinopathy

THK Vu, H Chen, L Pan, KS Cho, D Doesburg… - The American Journal of …, 2020 - Elsevier
Retinal ischemic events, which result from occlusion of the ocular vasculature share similar
causes as those for central nervous system stroke and are among the most common cause …

Immune cells in subretinal wound healing and fibrosis

M Szczepan, M Llorián-Salvador, M Chen… - Frontiers in Cellular …, 2022 - frontiersin.org
The subretinal space is devoid of any immune cells under normal conditions and is an
immune privileged site. When photoreceptors and/or retinal pigment epithelial cells suffer …

Minocycline modulates microglia polarization in ischemia-reperfusion model of retinal degeneration and induces neuroprotection

A Ahmed, LL Wang, S Abdelmaksoud, A Aboelgheit… - Scientific reports, 2017 - nature.com
Retinal ischemia-reperfusion (IR) injury causes irreversible loss of neurons and ultimately
leads to permanent visual impairment and blindness. The cellular response under this …

Optic nerve degeneration after retinal ischemia/reperfusion in a rodent model

M Renner, G Stute, M Alzureiqi, J Reinhard… - Frontiers in cellular …, 2017 - frontiersin.org
Retinal ischemia is a common pathomechanism in many ocular disorders such as age-
related macular degeneration (AMD), diabetic retinopathy, glaucoma or retinal vascular …

Colony-stimulating factor 1 receptor inhibition prevents disruption of the blood-retina barrier during chronic inflammation

D Kokona, A Ebneter, P Escher… - Journal of …, 2018 - Springer
Background Microglia-associated inflammation is closely related to the pathogenesis of
various retinal diseases such as uveitis and diabetic retinopathy, which are associated with …

[HTML][HTML] Vitreous cytokine expression and a murine model suggest a key role of microglia in the inflammatory response to retinal detachment

L Kiang, BX Ross, J Yao, S Shanmugam… - … & visual science, 2018 - tvst.arvojournals.org
Purpose: Retinal detachment (RD) separates the retina from the underlying retinal pigment
epithelium, resulting in a gradual degeneration of photoreceptor (PR) cells. It is known that …

Blood-retinal barrier breakdown following experimental retinal ischemia and reperfusion

CA Wilson, BA Berkowitz, H Funatsu, DC Metrikin… - Experimental eye …, 1995 - Elsevier
The purpose of this study was to examine the effects of acute ischemia and reperfusion on
blood-retinal barrier (BRB) function in the rabbit eye. Hydrostatic pressure (140 mmHg) was …

Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury

Q Qin, N Yu, Y Gu, W Ke, Q Zhang, X Liu, K Wang… - Cell death & …, 2022 - nature.com
Progressive retinal ganglion cells (RGCs) death that triggered by retinal ischemia
reperfusion (IR), leads to irreversible visual impairment and blindness, but our knowledge of …

Interleukin-6 in retinal ischemia reperfusion injury in rats

RN Sanchez, CK Chan, S Garg… - … & visual science, 2003 - iovs.arvojournals.org
purpose. To study the role of interleukin (IL)-6 after retinal ischemia–reperfusion (I/R) injury
in rats. methods. Intraocular pressure of adult male Lewis albino rats was raised to create …

Models of microglia depletion and replenishment elicit protective effects to alleviate vascular and neuronal damage in the diabetic murine retina

KA Church, D Rodriguez, D Vanegas… - Journal of …, 2022 - Springer
Microglia, the resident phagocytes of the retina, are believed to influence the development of
retinopathy, but their exact contributions to vascular integrity and neuronal loss are …