Hemorrhage under the neural retina (subretinal hemorrhage) can occur in the context of age-
related macular degeneration and induce subsequent photoreceptor cell death and …

Purpose Transient retinal ischemia induces the death of retinal neuronal cells. Postischemic
damage is associated with the infiltration of leukocytes into the neural tissue through …

Retinal ischemia/reperfusion injury (RI) is a common cause of irreversible visual impairment
and blindness in elderly and critical unmet medical need. While no effective treatment is …

Microglia are the primary resident retinal macrophages that monitor neuronal activity in real-
time and facilitate angiogenesis during retinal development. In certain retinal diseases, the …

Background Microglia and inflammation have context-specific impacts upon neuronal
survival in different models of central nervous system (CNS) disease. Herein, we investigate …

Purpose We investigated whether retinal ischemia and inflammation produced by raising the
intraocular pressure above normal systolic levels differs in mice that lack a functional toll-like …

Nonarteritic anterior ischemic optic neuropathy (NAION) results from isolated anterior optic
nerve (ON)-axonal ischemia near the retina–optic nerve junction. We utilized a rodent model …

Although permanent bilateral common carotid artery occlusion (2VO) has been
demonstrated to induce retinal injury, there is still a lack of systematic research on the …

Purpose This study aimed to explore cellular localisation of CD38 in the retina and evaluate
the role and potential mechanism of CD38 deficiency in retinal ischaemia/reperfusion (I/R) …

Background Diabetic retinopathy and retinal vein occlusion are vision threatening retinal
vascular diseases. Current first-line therapy targets the vascular component, but many …