Background Chemokine signalling is required for the homing of leukocytes during retinal
inflammation, and is associated with pathogenesis of diseases such as age-related macular …

Recent reports have indicated that components of the complement cascade are synthesized
during the degeneration of retinal ganglion cells (RGC) in glaucoma. While complement …

Background Traumatic brain injury (TBI) is a major cause of death and disability in the USA
and the world; it constitutes 30% of injury-related deaths (Taylor et al., MMWR Surveill …

Background During inflammatory conditions of the central nervous system (CNS), the
protective function of the blood-brain barrier (BBB) may be compromised, resulting in CNS …

Several barriers separate the central nervous system (CNS) from the rest of the body. These
barriers are essential for regulating the movement of fluid, ions, molecules, and immune …

Background Neuron loss, glial activation and vascular degeneration are common sequelae
of ischemia-reperfusion (I/R) injury in ocular diseases. The present study was conducted to …

Background Following injury to the central nervous system, increased microglia, secretion of
pro-and anti-inflammatory cytokines, and altered blood-brain barrier permeability, a hallmark …

purpose. To evaluate chemokine expression at various retinal sites after ischemia–
reperfusion injury, using reverse transcription–polymerase chain reaction (RT-PCR) …

The retinal pigment epithelium (RPE) has been reported to demonstrate feasible self-
regenerative potential under specific conditions. However, the precise underlying …

In adult Sprague–Dawley rats we have investigated retinal ganglion cell survival after
transient intervals of retinal ischemia of 30, 45, 60, 90 or 120 min duration, induced by …