Antidiabetic effect of green rooibos (Aspalathus linearis) extract in cultured cells and type 2 diabetic model KK-Ay mice

R Kamakura, MJ Son, D de Beer, E Joubert, Y Miura… - Cytotechnology, 2015 - Springer
Previous studies have demonstrated antidiabetic effects for rooibos (Aspalathus linearis)
and aspalathin (ASP), one of its main polyphenols. Rooibos, an endemic plant of South …

Aspalathin improves hyperglycemia and glucose intolerance in obese diabetic ob/ob mice

MJ Son, M Minakawa, Y Miura, K Yagasaki - European journal of nutrition, 2013 - Springer
Purpose Although several researches have demonstrated that rooibos extract has
hypoglycemic effect, the role of aspalathin, a main polyphenol in the extract, remains …

Hypoglycemic effect of aspalathin, a rooibos tea component from Aspalathus linearis, in type 2 diabetic model db/db mice

A Kawano, H Nakamura, S Hata, M Minakawa, Y Miura… - Phytomedicine, 2009 - Elsevier
Effects of aspalathin, a green rooibos tea component, on glucose metabolism were studied
in vitro and in vivo. We first examined the effect of aspalathin on glucose uptake by cultured …

Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential

CJF Muller, E Joubert, D De Beer, M Sanderson… - Phytomedicine, 2012 - Elsevier
Rooibos, an endemic South African plant, known for its use as herbal tea, has potential as
an antidiabetic herbal product, following recent demonstration of the glucose lowering effect …

Effects of Agriophyllum squarrosum extracts on glucose metabolism in KKAy mice and the associated underlying mechanisms

S Bao, S Han, W Ao - Journal of ethnopharmacology, 2019 - Elsevier
Ethnopharmacological relevance Agriophyllum squarrosum (L.) Moq. is a traditional Mongol
medicine commonly used in the treatment of diabetes. Aim of the study To examine the …

Therapeutic effects of an aspalathin-rich green rooibos extract, pioglitazone and atorvastatin combination therapy in diabetic db/db mice

O Patel, CJF Muller, E Joubert, B Rosenkranz, J Louw… - PloS one, 2021 - journals.plos.org
Oral therapeutics used to treat type 2 diabetes and cardiovascular disease often fail to
prevent the progression of disease and their comorbidities. Rooibos (Aspalathus linearis) …

Amelioration of palmitate-induced insulin resistance in C2C12 muscle cells by rooibos (Aspalathus linearis)

SE Mazibuko, CJF Muller, E Joubert, D De Beer… - Phytomedicine, 2013 - Elsevier
Increased levels of free fatty acids (FFAs), specifically saturated free fatty acids such as
palmitate are associated with insulin resistance of muscle, fat and liver. Skeletal muscle …

A beneficial role of rooibos in diabetes mellitus: a systematic review and meta-analysis

M Sasaki, N Nishida, M Shimada - Molecules, 2018 - mdpi.com
In a rapid increase in cases of diabetes mellitus worldwide, there has been interested in the
use of plant-derived polyphenols as nutraceuticals to prevent the onset and progression of …

Myocardial glucose clearance by aspalathin treatment in young, mature, and obese insulin-resistant rats

SE Smit, R Johnson, MA Van Vuuren… - Planta …, 2018 - thieme-connect.com
Rooibos, an indigenous South African plant ingested as herbal tea, is well known for its
antioxidant effects. This in vitro study investigated aspalathin (C 21 H 24 O 11), a …

Agriophyllum oligosaccharides ameliorate diabetic insulin resistance through INS-R/IRS/Glut4-mediated insulin pathway in db/db mice and MIN6 cells

S Bao, X Wang, SB Cho, YL Wu, C Wei… - Frontiers in …, 2021 - frontiersin.org
We have previously reported that Agriophyllum oligosaccharides (AOS) significantly
enhance glycemic control by increasing the activation of insulin receptor (INS-R), insulin …