Although the specific role of connexin-mediated gap junctional intercellular communication
in the control of cell homeostasis, proliferation, and death are still not clear, several lines of …

Gap junctional intercellular communication mediates the transfer of small molecules from the
cytoplasm of one cell to that of neighbouring cells. Connexins are the proteins that form the …

Results from short-term tests for carcinogens and our advanced knowledge on cellular and
molecular mechanisms of carcinogenesis strongly suggest that carcinogens do not induce …

Gap junctions, intercellular channels structured by the connexin protein family, have been
implicated in the control of cell homeostasis, proliferation, differentiation and death. A loss of …

Cells within a tissue continuously interact to coordinate normal tissue functions and maintain
homeostasis. Gap junctional communication (GJC), mediated by the connexin protein family …

Gap junctions, or connexons, are formed by connexin proteins and connect most cells in the
body to form water-filled channels directly linking the cytoplasm. Among the molecules …

Gap junctions are intercellular plasma membrane domains enriched in channels that allow
direct exchange of ions and small molecules between adjacent cells. Gap junction channels …

The development of the most efficacious strategy for the prevention and treatment of cancers
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …

Evidence is accumulating that connexin (Cx) genes form a family of tumor-suppressor
genes. Our long-standing study revealed that, in almost all tumors, some abnormality in gap …

Cancer was one of the first pathologies to be associated with gap-junction defect. Despite
the evidence accumulated over the last 40-year period, the molecular involvement of gap …