Neuronal ryanodine receptors in development and aging
N Abu-Omar, J Das, V Szeto, ZP Feng - Molecular neurobiology, 2018 - Springer
Ryanodine receptors (RyRs) are intracellular calcium-release channels found on the
endoplasmic reticulum of all cells. All three RyR isoforms, RyR1–3, are expressed in the …
endoplasmic reticulum of all cells. All three RyR isoforms, RyR1–3, are expressed in the …
Ryanodine receptors: physiological function and deregulation in Alzheimer disease
Abstract Perturbed Endoplasmic Reticulum (ER) calcium (Ca 2+) homeostasis emerges as a
central player in Alzheimer disease (AD). Accordingly, different studies have reported …
central player in Alzheimer disease (AD). Accordingly, different studies have reported …
Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease
Intracellular Ca2+ dysregulation is an underlying component of Alzheimer's disease (AD)
pathophysiology, and recent evidence implicates the ryanodine receptor (RyR) in the …
pathophysiology, and recent evidence implicates the ryanodine receptor (RyR) in the …
Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain
Ryanodine receptors (RyR) are Ca2+-induced Ca2+ release channels located on the
endoplasmic reticulum, and consist of three isoforms, termed RyR1-3. We examined their …
endoplasmic reticulum, and consist of three isoforms, termed RyR1-3. We examined their …
Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory
Abstract Ryanodine receptor 2 (RyR2) is abundantly expressed in the heart and brain.
Mutations in RyR2 are associated with both cardiac arrhythmias and intellectual disability …
Mutations in RyR2 are associated with both cardiac arrhythmias and intellectual disability …
Functional ryanodine receptors are expressed by human microglia and THP‐1 cells: Their possible involvement in modulation of neurotoxicity
A Klegeris, HB Choi, JG McLarnon… - Journal of …, 2007 - Wiley Online Library
Ryanodine receptors (RyRs) are intracellular Ca2+ channels that mediate the release of
calcium from internal stores and therefore play an important role in Ca2+ signaling and …
calcium from internal stores and therefore play an important role in Ca2+ signaling and …
Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum
C Martin, KE Chapman, JR Seckl, RH Ashley - Neuroscience, 1998 - Elsevier
Cellular Ca2+ signalling is an important factor in the control of neuronal metabolism and
electrical activity. Although the roles of Ca2+-release channels are well established for …
electrical activity. Although the roles of Ca2+-release channels are well established for …
[HTML][HTML] Ryanodine receptor studies using genetically engineered mice
A Kushnir, MJ Betzenhauser, AR Marks - FEBS letters, 2010 - Elsevier
Ryanodine receptors (RyR) regulate intracellular Ca2+ release in many cell types and have
been implicated in a number of inherited human diseases. Over the past 15years genetically …
been implicated in a number of inherited human diseases. Over the past 15years genetically …
Ryanodine receptor physiology and its role in disease
JT Lanner - Calcium Signaling, 2012 - Springer
The ryanodine receptors (RyRs) is the major intracellular Ca 2+ release channel localized in
the plasma membrane of the endoplasmatic/sarcoplasmatic reticulum. RyR-mediated Ca 2+ …
the plasma membrane of the endoplasmatic/sarcoplasmatic reticulum. RyR-mediated Ca 2+ …
Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits
A Lacampagne, X Liu, S Reiken, R Bussiere… - Acta …, 2017 - Springer
The mechanisms underlying ryanodine receptor (RyR) dysfunction associated with
Alzheimer disease (AD) are still not well understood. Here, we show that neuronal RyR2 …
Alzheimer disease (AD) are still not well understood. Here, we show that neuronal RyR2 …