Ryanodine receptors (RyRs) are intracellular calcium-release channels found on the
endoplasmic reticulum of all cells. All three RyR isoforms, RyR1–3, are expressed in the …

Abstract Perturbed Endoplasmic Reticulum (ER) calcium (Ca 2+) homeostasis emerges as a
central player in Alzheimer disease (AD). Accordingly, different studies have reported …

Intracellular Ca2+ dysregulation is an underlying component of Alzheimer's disease (AD)
pathophysiology, and recent evidence implicates the ryanodine receptor (RyR) in the …

Ryanodine receptors (RyR) are Ca2+-induced Ca2+ release channels located on the
endoplasmic reticulum, and consist of three isoforms, termed RyR1-3. We examined their …

Abstract Ryanodine receptor 2 (RyR2) is abundantly expressed in the heart and brain.
Mutations in RyR2 are associated with both cardiac arrhythmias and intellectual disability …

Ryanodine receptors (RyRs) are intracellular Ca2+ channels that mediate the release of
calcium from internal stores and therefore play an important role in Ca2+ signaling and …

Cellular Ca2+ signalling is an important factor in the control of neuronal metabolism and
electrical activity. Although the roles of Ca2+-release channels are well established for …

Ryanodine receptors (RyR) regulate intracellular Ca2+ release in many cell types and have
been implicated in a number of inherited human diseases. Over the past 15years genetically …

The ryanodine receptors (RyRs) is the major intracellular Ca 2+ release channel localized in
the plasma membrane of the endoplasmatic/sarcoplasmatic reticulum. RyR-mediated Ca 2+ …

The mechanisms underlying ryanodine receptor (RyR) dysfunction associated with
Alzheimer disease (AD) are still not well understood. Here, we show that neuronal RyR2 …