Background: Metabolic dysfunction links to cognitive deficits in Alzheimer's disease (AD).
Leptin is an anti-obesity hormone that modulates energy homeostasis and memory function …

Leptin, as a link between fat mass and the brain, has been reported to be associated with
gender. The gender differences in leptin levels between Alzheimer's disease (AD) and …

Background Metabolic dysfunction and dysregulation of leptin signaling have been linked to
Alzheimer's disease (AD)'s pathophysiology. The objectives of this study were to examine …

Analysis of data derived from the Alzheimer's Disease Neuroimaging Initiative (ADNI)
program showed plasma leptin levels in individuals with Mild Cognitive Impairment (MCI) or …

It is well documented that the hormone leptin regulates several hypothalamic-driven
functions, including energy homeostasis and reproductive function. However, recent studies …

There is accumulating evidence from epidemiological studies that changes in body weight
are associated with Alzheimer's disease (AD) from mid-life obesity increasing the risk of …

Background: There is growing interest in the pathophysiological processes of preclinical
Alzheimer's disease (AD), including the potential role of leptin. Human studies have shown …

Weight loss is common in Alzheimer's disease (AD) and is predictive of mortality. Leptin, an
adipocyte-derived peptide hormone is implicated in the regulation of satiety and energy …

Importance Many epidemiologic studies have suggested that low levels of plasma leptin, a
major adipokine, are associated with increased risk of Alzheimer disease (AD) dementia …

Context The adipokine leptin facilitates long-term potentiation and synaptic plasticity in the
hippocampus, promotes β-amyloid clearance, and improves memory function in animal …