Abstract Heme oxygenase (HO)-1, the inducible isoform of the heme-degrading enzyme HO,
plays a critical role in inflammation and iron homeostasis. Regulatory functions of HO-1 are …

Heme oxygenase (HO)-1 is an inducible enzyme that catalyzes the first and rate-limiting step
in the oxidative degradation of free heme into ferrous iron, carbon monoxide (CO), and …

Heme oxygenase (HO)-1 is the inducible isoform of the first and rate-limiting enzyme of
heme degradation. Induction of HO-1 protects against the cytotoxicity of oxidative stress and …

The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

The heme-heme oxygenase system has recently been recognized to possess important
regulatory properties. It is tightly involved in both physiological as well as pathophysiological …

HO-1 (haem oxygenase-1) is a ubiquitously expressed inducible enzyme degrading haem
to CO, biliverdin and Fe2+. Its activation reduces oxidative stress in cells and inhibits …

Abstract Heme oxygenase-1 (HO-1) catalyzes the first and rate-limiting enzymatic step of
heme degradation and produces carbon monoxide, free iron, and biliverdin. HO-1, a stress …

Organisms on our planet have evolved in an oxidizing environment that is intrinsically
inimical to life, and cells have been forced to devise means of protecting themselves. One of …

Heme Oxygenase is the rate-limiting enzyme in the degradation of heme into carbon
monoxide (CO), iron and bilirubin. To date, three heme oxygenase isozymes have been …

The heme oxygenase (HO) system is essential for heme and iron homeostasis and
necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon …