Cullin–RING complexes comprise the largest known class of ubiquitin ligases. Owing to the
great diversity of their substrate-receptor subunits, it is possible that there are hundreds of …

Cullin-RING ubiquitin ligases (CRLs) comprise the largest known category of ubiquitin
ligases. CRLs regulate an extensive number of dynamic cellular processes, including …

Ubiquitination is a highly conserved post-translational modification in eukaryotes, well
known for targeting proteins for degradation by the 26S proteasome. Proteins destined for …

Cullins are members of a family of scaffold proteins that assemble multisubunit ubiquitin
ligase complexes to confer substrate specificity for the ubiquitination pathway. Cullin3 (Cul3) …

Cullin-RING ubiquitin ligases (CRLs) are dynamic modular platforms that regulate myriad
biological processes through target-specific ubiquitylation. Our knowledge of this system …

Cullin-RING ligases (CRLs) represent the largest E3 ubiquitin ligase family in eukaryotes,
and the identification of their substrates is critical to understanding regulation of the …

The cullin-RING ubiquitin ligases (CRLs) are the largest family of multi-subunit E3 ligases in
eukaryotes, which ubiquitinate protein substrates in numerous cellular pathways. CRLs …

Cullin‐based E3 ligases target substrates for ubiquitin‐dependent degradation by the 26S
proteasome. The SCF (Skp1–Cul1–F‐box) and ECS (ElonginC–Cul2–SOCS box) …

Cullin-RING E3 ubiquitin-Ligases (CRLs) are the most prominent class of ubiquitin-ligases.
By controlling the stability of a cohort of key regulators, CRLs impinge on many cellular and …

Cullins (CULs) are subunits of a prominent class of RING ubiquitin ligases. Whereas the
subunits and substrates of CUL1-associated SCF complexes and CUL2 ubiquitin ligases …