Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases
(CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all …

Interstitial fibrosis is the common endpoint of end-stage chronic kidney disease (CKD)
leading to kidney failure. The clinical course of many renal diseases, and thereby of CKD, is …

Chronic kidney disease (CKD) is characterized by pathological accumulation of extracellular
matrix (ECM) proteins in renal structures. Tubulointerstitial fibrosis is observed in glomerular …

Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

Over the past two decades, the concept of the epithelial to mesenchymal transition (EMT)
has been imported from embryology and oncology to fibrosis, particularly in the kidney. This …

Tubulointerstitial injury is one of the hallmarks of renal disease. In particular, interstitial
fibrosis has a prominent role in the development and progression of kidney injury. Collagen …

Kidney fibrosis is the unavoidable consequence of chronic kidney disease irrespective of the
primary underlying insult. It is a complex phenomenon governed by the interplay between …

The extracellular matrix (ECM) is a complex three-dimensional network of proteins
surrounding cells, forming a niche that controls cell adhesion, proliferation, migration and …

All types of progressive chronic kidney disease (CKD) inevitably induce renal fibrosis, the
hallmark of which is the activation and accumulation of a large number of matrix-producing …

Abstract Epithelial-mesenchymal transition (EMT), a process by which differentiated
epithelial cells undergo a phenotypic conversion that gives rise to the matrix-producing …