Acquisition, maintenance and relapse-like alcohol drinking: lessons from the UChB rat line
This review article addresses the biological factors that influence:(i) the acquisition of
alcohol intake;(ii) the maintenance of chronic alcohol intake; and (iii) alcohol relapse-like …
alcohol intake;(ii) the maintenance of chronic alcohol intake; and (iii) alcohol relapse-like …
N-Acetylcysteine and acetylsalicylic acid inhibit alcohol consumption by different mechanisms: combined protection
Chronic ethanol intake results in brain oxidative stress and neuroinflammation, which have
been postulated to perpetuate alcohol intake and to induce alcohol relapse. The present …
been postulated to perpetuate alcohol intake and to induce alcohol relapse. The present …
Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse‐like drinking in high‐alcohol drinker rats
Neuroinflammation has been reported to follow chronic ethanol intake and may perpetuate
alcohol consumption. Present studies determined the effect of human mesenchymal stem …
alcohol consumption. Present studies determined the effect of human mesenchymal stem …
Aspirin and N‐acetylcysteine co‐administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation‐oxidative stress …
Chronic alcohol intake leads to neuroinflammation and cell injury, proposed to result in
alterations that perpetuate alcohol intake and cued relapse. Studies show that brain …
alterations that perpetuate alcohol intake and cued relapse. Studies show that brain …
What is in that drink: the biological actions of ethanol, acetaldehyde, and salsolinol
Alcohol abuse and alcoholism represent substantial problems that affect a large portion of
individuals throughout the world. Extensive research continues to be conducted in an effort …
individuals throughout the world. Extensive research continues to be conducted in an effort …
Exercise reverses ethanol inhibition of neural stem cell proliferation
Neural stem cells in the adult brain may contribute to learning and neural plasticity, to stress-
induced neuropathologic changes, to mood and affective disorders, and to other complex …
induced neuropathologic changes, to mood and affective disorders, and to other complex …
Behavioral and neurochemical studies in distinct animal models of ethanol's motivational effects
R Camarini, R Marcos Pautassi… - Current Drug Abuse …, 2010 - ingentaconnect.com
In the last decades, the goal of creating a unique and complete model of alcohol use and
alcoholism has been replaced by a myriad of different animal models, each addressing a …
alcoholism has been replaced by a myriad of different animal models, each addressing a …
Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar‐Derived UChB Rats: Inhibition by N‐Acetylcysteine
Background Life expectancy is greatly reduced in individuals presenting alcohol use
disorders and chronic smoking. Literature studies suggest that common mechanisms may …
disorders and chronic smoking. Literature studies suggest that common mechanisms may …
Beyond the “First Hit”: Marked Inhibition by N‐Acetyl Cysteine of Chronic Ethanol Intake But Not of Early Ethanol Intake. Parallel Effects on Ethanol‐Induced …
ME Quintanilla, M Rivera‐Meza… - Alcoholism: Clinical …, 2016 - Wiley Online Library
Background A number of studies have shown that acetaldehyde synthesized in the brain is
necessary to induce ethanol (EtOH) reinforcement in naïve animals (acquisition phase) …
necessary to induce ethanol (EtOH) reinforcement in naïve animals (acquisition phase) …
Transplantation of bone marrow mesenchymal stem cells promotes learning and memory functional recovery and reduces hippocampal damage in rats with alcohol …
HY Yang, XM Wu, Y Liu, D He - Transplantation, 2015 - journals.lww.com
Background Chronic ethanol exposure leads to permanent damage to the central nervous
system and produces cognitive deficits such as learning and memory impairment. The …
system and produces cognitive deficits such as learning and memory impairment. The …