Pancreatic β-cells are finely tuned to secrete insulin so that plasma glucose levels are
maintained within a narrow physiological range (3.5-5.5 mmol/L). Hyperinsulinaemic …

Congenital hyperinsulinism (CHI) is a rare disease characterized by an unregulated insulin
release, leading to hypoglycaemia. It is the most frequent cause of persistent and severe …

Insulin secretion from pancreatic β-cells is tightly regulated to keep fasting blood glucose
concentrations within the normal range (3.5-5.5 mmol/L). Hyperinsulinaemic hypoglycaemia …

Context: Congenital hyperinsulinism (HI) is the most common cause of hypoglycemia in
children. The risk of permanent brain injury in infants with HI continues to be as high as 25 …

Hyperinsulinaemic hypoglycaemia (HH) is characterized by unregulated insulin secretion
from pancreatic β-cells. Untreated hypoglycaemia in infants can lead to seizures …

Congenital hyperinsulinism is a cause of persistent hypoglycaemia in the neonatal period. It
is a heterogeneous disease with respect to clinical presentation, molecular biology, genetic …

Congenital hyperinsulinism (CHI) is the result of unregulated insulin secretion from the
pancreatic β-cells leading to severe hypoglycaemia. In these patients it is important to make …

Hyperinsulinism of infancy is a genetically heterogeneous disease characterized by
dysregulation of insulin secretion resulting in severe hypoglycemia. To date, mutations in …

Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the
unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic …

Congenital hyperinsulinism is a rare disease, but is the most frequent cause of persistent
and severe hypoglycaemia in early childhood. Hypoglycaemia caused by excessive and …